<abstract xmlns="http://www.w3.org/1999/xhtml">Madelung’s disease also called benign symmetric lipomatosis is a rare disorder of unknown etiology. The disease affects almost exclusively middle-aged men with a history of multi-year alcohol abuse. The major symptom is presence of non-encapsulated benign fat masses, especially in the area of the head and neck. Limited head and neck movement, dysphagia, and dyspnea may appear as well.The diagnosis is clinical and is supported by imaging methods, often elevated hepatic enzymes in blood serum, and histological examination with finding of mature adipose tissue without signs of proliferation. Therapeutic methods involve liposuction or excision which is a method of choice nowadays.In this article the authors review current knowledge, research state, and present five cases of the Madelung’s disease occurring within the last 10 years at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Martin, Slovakia.</abstract>

Madelung’s disease also called benign symmetric lipomatosis is a rare disorder of unknown etiology. The disease affects almost exclusively middle-aged men with a history of multi-year alcohol abuse. The major symptom is presence of non-encapsulated benign fat masses, especially in the area of the head and neck. Limited head and neck movement, dysphagia, and dyspnea may appear as well.The diagnosis is clinical and is supported by imaging methods, often elevated hepatic enzymes in blood serum, and histological examination with finding of mature adipose tissue without signs of proliferation. Therapeutic methods involve liposuction or excision which is a method of choice nowadays.In this article the authors review current knowledge, research state, and present five cases of the Madelung’s disease occurring within the last 10 years at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Martin, Slovakia.

Madelung’s disease: case series and literature review

Clinic of Otorhinolaryngology and Head and Neck Surgery, Jessenius Faculty of Medicine in Martin

Comenius University in Bratislava, and Martin University Hospital

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Madelung\u2019s disease: case series and literature review"}

Madelung’s disease also called benign symmetric lipomatosis is a rare disorder of unknown etiology. The disease affects almost exclusively middle-aged men with...

Madelung’s disease: case series and literature review

Published Online: Aug 06, 2018

Page range: 30 - 34

Received: Mar 31, 2018

Accepted: Jun 18, 2018

DOI: https://doi.org/10.2478/acm-2018-0004

Keywords
Madelung’s disease, lipomatosis, benign symmetric lipomatosis

© 2018 H Pedan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Madelung’s disease: case series and literature review

Published Online: Aug 06, 2018

Page range: 30 - 34

Received: Mar 31, 2018

Accepted: Jun 18, 2018

DOI: https://doi.org/10.2478/acm-2018-0004

KeywordsMadelung’s disease, lipomatosis, benign symmetric lipomatosis

© 2018 H Pedan et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Madelung’s disease, lipomatosis, benign symmetric lipomatosis