<abstract xmlns="http://www.w3.org/1999/xhtml"> Histamine is one of the most important biogenic amines and it mediates numbers of physiological processes. It is also involved in majority of inflammatory diseases via its receptors H1, H2, H3 and H4. The role of histamine had been recognized as substantial in many allergic diseases including bronchial asthma, thus the histamine receptor antagonists (H1) are frequently used in the clinical practice as potent anti-allergic and anti-inflammatory drugs. However, first generation of antihistamines have also adverse effects, predominantly sedation, changes in appetite and many more, and they are still not fully effective in all patients. Attention is now focused mainly on H3 and H4 receptor antagonists and their potential clinical applications. This review focuses basically on the H3 receptor, its expression pattern and some effects which are mediated by H3, discussing its clinical relevance</abstract>

Histamine is one of the most important biogenic amines and it mediates numbers of physiological processes. It is also involved in majority of inflammatory diseases via its receptors H1, H2, H3 and H4. The role of histamine had been recognized as substantial in many allergic diseases including bronchial asthma, thus the histamine receptor antagonists (H1) are frequently used in the clinical practice as potent anti-allergic and anti-inflammatory drugs. However, first generation of antihistamines have also adverse effects, predominantly sedation, changes in appetite and many more, and they are still not fully effective in all patients. Attention is now focused mainly on H3 and H4 receptor antagonists and their potential clinical applications. This review focuses basically on the H3 receptor, its expression pattern and some effects which are mediated by H3, discussing its clinical relevance

Histamine and its Effects Mediated via H3 Receptor – Potential Clinical Applications of H3 Antagonists

Department of Pathological Physiology, Jessenius Faculty of Medicine in Martin, Comenius University, Slovak Republic

Acta Medica Martiniana

Histamine and its Effects Mediated via H Receptor – Potential Clinical Applications of H Antagonists

Histamine is one of the most important biogenic amines and it mediates numbers of physiological processes. It is also involved in majority of inflammatory...

Histamine and its Effects Mediated via H₃ Receptor – Potential Clinical Applications of H₃ Antagonists

Published Online: May 09, 2013

Page range: 28 - 36

DOI: https://doi.org/10.2478/acm-2013-0004

Keywords
histamine - histamine receptor - expression - allergies - neurons

This content is open access.