<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The human insulin-like growth factor (IGF) system has attracted significant researcher interest due to its endocrine and autocrine / paracrine activities, mitogenic effects and the involvement in the regulation of proliferation, differentiation and apoptosis. The signaling pathways used by the IGF system impact cellular metabolism in a complex manner complex and many details are still unclear. Understanding the molecular mechanism of action of IGF’s and their effects on cellular activity may provide a basis to develop new anticancer drugs. This review focuses on recent studies that expand our knowledge of the signaling pathways of IGF system</p></abstract>

The human insulin-like growth factor (IGF) system has attracted significant researcher interest due to its endocrine and autocrine / paracrine activities, mitogenic effects and the involvement in the regulation of proliferation, differentiation and apoptosis. The signaling pathways used by the IGF system impact cellular metabolism in a complex manner complex and many details are still unclear. Understanding the molecular mechanism of action of IGF’s and their effects on cellular activity may provide a basis to develop new anticancer drugs. This review focuses on recent studies that expand our knowledge of the signaling pathways of IGF system

The Role of Human Insulin Growth Factor (Igf) – Axis in Carcinogenesis

Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Staszica 16 Street, 20-081 Lublin

Chair and Department of Obstetrics and Pathology of Pregnancy, Medical University in Lublin, Staszica 16 Street, 20-081 Lublin

Chair and Department of Oncological Gynaecology and Gynaecology, Medical University in Lublin, Staszica 16 Street, 20-081 Lublin

Department of Virology, Institute of Experimental Biology, Adam Mickiewicz University in Poznań, Staszica 16 Street, 20-081 Lublin

Chair and Department of Oncological Gynaecology and Gynaecology, Staszica 16 Street, 20-081 Lublin

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Role of Human Insulin Growth Factor (Igf) \u2013 Axis in Carcinogenesis"}

The human insulin-like growth factor (IGF) system has attracted significant researcher interest due to its endocrine and autocrine / paracrine activities,...

The Role of Human Insulin Growth Factor (Igf) – Axis in Carcinogenesis

Published Online: Oct 15, 2014

Page range: 25 - 42

DOI: https://doi.org/10.2478/acb-2014-0002

Keywords
IGFI, IGF-R, IGFBP, signaling pathways

© by Wojciech Kwaśniewski

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Role of Human Insulin Growth Factor (Igf) – Axis in Carcinogenesis

Published Online: Oct 15, 2014

Page range: 25 - 42

DOI: https://doi.org/10.2478/acb-2014-0002

KeywordsIGFI, IGF-R, IGFBP, signaling pathways

© by Wojciech Kwaśniewski

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
IGFI, IGF-R, IGFBP, signaling pathways