<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Acetaminophen (APAP) is a commonly used over-the-counter (OTC) drug known to induce hepatotoxicity when consumed in excess. Formation of reactive oxygen species (ROS) and oxidation of cellular proteins and enzymes are directly involved in its toxic mechanisms. However, antioxidants can be helpful to inhibit or restrict the oxidative damage. Besides synthetic antioxidants, naturally-derived substances can be used to serve the purpose. In this paper, a thorough literature review revealed that APAP combined with food-derived natural antioxidants exhibit a protective effect against APAP-induced hepatotoxicity.</p>
</abstract>

Acetaminophen (APAP) is a commonly used over-the-counter (OTC) drug known to induce hepatotoxicity when consumed in excess. Formation of reactive oxygen species (ROS) and oxidation of cellular proteins and enzymes are directly involved in its toxic mechanisms. However, antioxidants can be helpful to inhibit or restrict the oxidative damage. Besides synthetic antioxidants, naturally-derived substances can be used to serve the purpose. In this paper, a thorough literature review revealed that APAP combined with food-derived natural antioxidants exhibit a protective effect against APAP-induced hepatotoxicity.

Protective Effect of Naturally-Derived Antioxidants Against Acetaminophen-Induced Hepatotoxicity: A Review

Bangabandhu Sheikh Mujibur Rahman Science and Technology University

Department of Biochemistry, Medicinal Biochemistry, Infectious Diseases, Nanomedicine & Toxicology Laboratory

Acta Biologica Marisiensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Acetaminophen (APAP) is a commonly used over-the-counter (OTC) drug known to induce hepatotoxicity when consumed in excess. Formation of reactive oxygen...

Protective Effect of Naturally-Derived Antioxidants Against Acetaminophen-Induced Hepatotoxicity: A Review

Published Online: Jan 05, 2021

Page range: 36 - 47

Received: Nov 20, 2020

Accepted: Dec 18, 2020

DOI: https://doi.org/10.2478/abmj-2020-0009

Keywords
acetaminophen, chemoprevention, hepatotoxicity, free radical, natural antioxidants, redox homeostasis

© 2020 Md. Mizanur Rahaman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Protective Effect of Naturally-Derived Antioxidants Against Acetaminophen-Induced Hepatotoxicity: A Review

Published Online: Jan 05, 2021

Page range: 36 - 47

Received: Nov 20, 2020

Accepted: Dec 18, 2020

DOI: https://doi.org/10.2478/abmj-2020-0009

Keywordsacetaminophen, chemoprevention, hepatotoxicity, free radical, natural antioxidants, redox homeostasis

© 2020 Md. Mizanur Rahaman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
acetaminophen, chemoprevention, hepatotoxicity, free radical, natural antioxidants, redox homeostasis