<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Isoflavonoids are phytoestrogenic compounds found mainly in plants from the Fabaceae family and also in soy-based foods. Isoflavonoids exhibit (anti)estrogenic effects, acting on estrogen receptors due to the structural similarities with estrogenic hormones (17β-estradiol). The aim of our minireview is to highlight the pharmacokinetic and pharmacodynamic properties of isoflavonoids, in order to sustain the beneficial effects in different pathologies (osteoporosis associated with menopause, breast cancer, prostate cancer, protective cognitive functions) but, at the same time, to aware about the possible adverse effects on long-term administration.</p></abstract>

Isoflavonoids are phytoestrogenic compounds found mainly in plants from the Fabaceae family and also in soy-based foods. Isoflavonoids exhibit (anti)estrogenic effects, acting on estrogen receptors due to the structural similarities with estrogenic hormones (17β-estradiol). The aim of our minireview is to highlight the pharmacokinetic and pharmacodynamic properties of isoflavonoids, in order to sustain the beneficial effects in different pathologies (osteoporosis associated with menopause, breast cancer, prostate cancer, protective cognitive functions) but, at the same time, to aware about the possible adverse effects on long-term administration.

Isoflavonoids − Dual Action on Estrogen Receptors

Department of Fundamental Pharmaceutical Sciences, Discipline of Biochemistry and Environmental Chemistry

University of Medicine, Pharmacy, Sciences and Technology of Tîrgu Mureș

Department of Fundamental Pharmaceutical Sciences, Discipline of Analytical Chemistry and Drug Analysis

Acta Biologica Marisiensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Isoflavonoids − Dual Action on Estrogen Receptors"}

Isoflavonoids are phytoestrogenic compounds found mainly in plants from the Fabaceae family and also in soy-based foods. Isoflavonoids exhibit (anti)estrogenic...

Isoflavonoids − Dual Action on Estrogen Receptors

Published Online: Jun 08, 2020

Page range: 61 - 67

Received: Nov 04, 2018

Accepted: Nov 17, 2018

DOI: https://doi.org/10.2478/abmj-2018-0014

Keywords
isoflavonoids, estrogen, receptors, menopause, SERM

© 2018 Amalia Miklos et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Isoflavonoids − Dual Action on Estrogen Receptors

Published Online: Jun 08, 2020

Page range: 61 - 67

Received: Nov 04, 2018

Accepted: Nov 17, 2018

DOI: https://doi.org/10.2478/abmj-2018-0014

Keywordsisoflavonoids, estrogen, receptors, menopause, SERM

© 2018 Amalia Miklos et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
isoflavonoids, estrogen, receptors, menopause, SERM