<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is a complex, progressive, and highly heterogeneous malignancy, which occurs via a multistep transformation process involving primary and secondary oncogenic events. Recent advances in molecular techniques have further expanded our understanding of the mutational landscape, clonal composition, and dynamic evolution patterns of MM. The first part of this review describes the key oncogenic events involved in the initiation and progression of MM, together with their prognostic impact. The latter part highlights the most prominent findings concerning genomic aberrations promoted by gene expression profiling (GEP) and next-generation sequencing (NGS) in MM. This review provides a concise understanding of the molecular pathogenesis of the MM genome and the importance of adopting emerging molecular technology in future clinical management of MM.</p>
</abstract>

Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is a complex, progressive, and highly heterogeneous malignancy, which occurs via a multistep transformation process involving primary and secondary oncogenic events. Recent advances in molecular techniques have further expanded our understanding of the mutational landscape, clonal composition, and dynamic evolution patterns of MM. The first part of this review describes the key oncogenic events involved in the initiation and progression of MM, together with their prognostic impact. The latter part highlights the most prominent findings concerning genomic aberrations promoted by gene expression profiling (GEP) and next-generation sequencing (NGS) in MM. This review provides a concise understanding of the molecular pathogenesis of the MM genome and the importance of adopting emerging molecular technology in future clinical management of MM.

Molecular genetic aberrations in the pathogenesis of multiple myeloma

Hematology Unit, Cancer Research Center, Institute for Medical Research

Asian Biomedicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Molecular genetic aberrations in the pathogenesis of multiple myeloma"}

Multiple myeloma (MM) is the second most common form of blood cancer characterized by clonal expansion of malignant plasma cells within the bone marrow. MM is...

Molecular genetic aberrations in the pathogenesis of multiple myeloma

Article Category: Review

Published Online: Oct 18, 2023

Page range: 152 - 162

DOI: https://doi.org/10.2478/abm-2023-0056

Keywords
genomic aberrations, molecular pathogenesis, multiple myeloma, mutational landscape, oncogenic events

© 2023 Ivyna Pau Ni Bong et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Molecular genetic aberrations in the pathogenesis of multiple myeloma

Article Category: Review

Published Online: Oct 18, 2023

Page range: 152 - 162

DOI: https://doi.org/10.2478/abm-2023-0056

Keywordsgenomic aberrations, molecular pathogenesis, multiple myeloma, mutational landscape, oncogenic events

© 2023 Ivyna Pau Ni Bong et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
genomic aberrations, molecular pathogenesis, multiple myeloma, mutational landscape, oncogenic events