<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>Transient tachypnea of the newborn (TTN) is the consequence of delayed resorption of lung fluid. When TTN develops, the infant may develop severe hypoxemia and progress to persistent pulmonary hypertension of the newborn (PPHN).</p>
</sec>
<sec><h3>Objectives</h3>
<p>To examine factors associated with the development of PPHN in TTN infants.</p>
</sec>
<sec><h3>Methods</h3>
<p>This retrospective study comprised 23 infants in whom a diagnosis of TTN with PPHN (TTN-PPHN) was confirmed and 59 infants with severe TTN without PPHN who required mechanical ventilation between 2009 and 2018 at Songklanagarind Hospital, Thailand. Logistic regression was used to assess factors associated with TTN and PPHN.</p>
</sec>
<sec><h3>Results</h3>
<p>The factors identified by univariate analysis that were associated with development of PPHN were oxygen saturation (SpO<sub>2</sub>) &lt;90% and respiratory rate (RR) ≥70 breaths/min at the time of admission, mean airway pressure (MAP) ≥8 cmH<sub>2</sub>O, oxygen index (OI) ≥10, partial pressure of oxygen (PaO<sub>2</sub>) ≤60, partial pressure of carbon dioxide (PCO<sub>2</sub>) ≥45 mmHg, and infants who did not receive positive pressure ventilation (PPV). In multivariate analyses, RR ≥70 breaths/min (adjusted odds ratio [aOR] 9.96, 95% confidence interval [CI] 2.1–47.29, <italic>P</italic> &lt; 0.001) and OI ≥10 (aOR 29.22, 95% CI 4.46–191.23, <italic>P</italic> &lt; 0.001) remained statistically significantly associated with PPHN.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>High RR and high OI were factors associated with PPHN in TTN infants.</p>
</sec>
</abstract>

Background
Transient tachypnea of the newborn (TTN) is the consequence of delayed resorption of lung fluid. When TTN develops, the infant may develop severe hypoxemia and progress to persistent pulmonary hypertension of the newborn (PPHN).

Objectives
To examine factors associated with the development of PPHN in TTN infants.

Methods
This retrospective study comprised 23 infants in whom a diagnosis of TTN with PPHN (TTN-PPHN) was confirmed and 59 infants with severe TTN without PPHN who required mechanical ventilation between 2009 and 2018 at Songklanagarind Hospital, Thailand. Logistic regression was used to assess factors associated with TTN and PPHN.

Results
The factors identified by univariate analysis that were associated with development of PPHN were oxygen saturation (SpO2) <90% and respiratory rate (RR) ≥70 breaths/min at the time of admission, mean airway pressure (MAP) ≥8 cmH2O, oxygen index (OI) ≥10, partial pressure of oxygen (PaO2) ≤60, partial pressure of carbon dioxide (PCO2) ≥45 mmHg, and infants who did not receive positive pressure ventilation (PPV). In multivariate analyses, RR ≥70 breaths/min (adjusted odds ratio [aOR] 9.96, 95% confidence interval [CI] 2.1–47.29, P < 0.001) and OI ≥10 (aOR 29.22, 95% CI 4.46–191.23, P < 0.001) remained statistically significantly associated with PPHN.

Conclusions
High RR and high OI were factors associated with PPHN in TTN infants.

Risk factors of transient tachypnea of the newborn developing into pulmonary hypertension of the newborn: a case-control study

Division of Neonatology, Department of Pediatrics, Faculty of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
Transient tachypnea of the newborn (TTN) is the consequence of delayed resorption of lung fluid. When TTN develops, the infant may develop severe...

Risk factors of transient tachypnea of the newborn developing into pulmonary hypertension of the newborn: a case-control study

Article Category: Brief communication (original)

Published Online: Aug 01, 2023

Page range: 310 - 315

DOI: https://doi.org/10.2478/abm-2022-0034

Keywords
case control, infant, newborn, pulmonary hypertension, risk factors, transient tachypnea of the newborn

© 2023 Gunlawadee Maneenil et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Risk factors of transient tachypnea of the newborn developing into pulmonary hypertension of the newborn: a case-control study

Article Category: Brief communication (original)

Published Online: Aug 01, 2023

Page range: 310 - 315

DOI: https://doi.org/10.2478/abm-2022-0034

Keywordscase control, infant, newborn, pulmonary hypertension, risk factors, transient tachypnea of the newborn

© 2023 Gunlawadee Maneenil et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
case control, infant, newborn, pulmonary hypertension, risk factors, transient tachypnea of the newborn