<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>The association between serum uric acid (SUA) levels and non-alcoholic fatty liver disease (NAFLD) is controversial.</p>
</sec>
<sec><h3>Objectives</h3>
<p>We compared the association of SUA levels with NAFLD, abnormal alanine transferase (ALT), and the degree of liver fibrosis to clarify the association of SUA levels with NAFLD.</p>
</sec>
<sec><h3>Methods</h3>
<p>We conducted a retrospective cross-sectional study. Adult patients who underwent a health check-up (N = 1,343) were included for analysis. Fatty liver was diagnosed by abdominal ultrasonography. The degree of liver fibrosis was determined using the NAFLD fibrosis score (NFS). Pearson correlation analysis showed a stronger correlation of SUA level with the fatty liver index (<italic>r</italic> = 0.40, <italic>P</italic> &lt; 0.001) than the correlation with serum ALT level (<italic>r</italic> = 0.28, <italic>P</italic> &lt; 0.001), or NFS (<italic>r</italic> = 0.018, <italic>P</italic> = 0.51). SUA levels in patients with NAFLD and an abnormal liver function test (LFT) result were significantly higher than levels in patients without NAFLD and abnormal LFT results. By contrast, there was no significant association of SUA level with NFS grade. When age, male sex, body mass index, the presence of hypertension, diabetic mellitus, and NAFLD, abnormality of ALT level, and SUA level were included in binary logistic regression to evaluate risk factors for elevated NFS grade, hyperuricemia was not significantly associated with NFS grade (OR = 0.94, <italic>P</italic> = 0.75).</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Pearson correlation and logistic regression together indicated SUA level is more closely associated with hepatic steatosis than abnormal liver function test or hepatic fibrosis.</p>
</sec>
</abstract>

Background
The association between serum uric acid (SUA) levels and non-alcoholic fatty liver disease (NAFLD) is controversial.

Objectives
We compared the association of SUA levels with NAFLD, abnormal alanine transferase (ALT), and the degree of liver fibrosis to clarify the association of SUA levels with NAFLD.

Methods
We conducted a retrospective cross-sectional study. Adult patients who underwent a health check-up (N = 1,343) were included for analysis. Fatty liver was diagnosed by abdominal ultrasonography. The degree of liver fibrosis was determined using the NAFLD fibrosis score (NFS). Pearson correlation analysis showed a stronger correlation of SUA level with the fatty liver index (r = 0.40, P < 0.001) than the correlation with serum ALT level (r = 0.28, P < 0.001), or NFS (r = 0.018, P = 0.51). SUA levels in patients with NAFLD and an abnormal liver function test (LFT) result were significantly higher than levels in patients without NAFLD and abnormal LFT results. By contrast, there was no significant association of SUA level with NFS grade. When age, male sex, body mass index, the presence of hypertension, diabetic mellitus, and NAFLD, abnormality of ALT level, and SUA level were included in binary logistic regression to evaluate risk factors for elevated NFS grade, hyperuricemia was not significantly associated with NFS grade (OR = 0.94, P = 0.75).

Conclusion
Pearson correlation and logistic regression together indicated SUA level is more closely associated with hepatic steatosis than abnormal liver function test or hepatic fibrosis.

Association between serum uric acid level and non-alcoholic fatty liver disease in Koreans

Asian Biomedicine

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
The association between serum uric acid (SUA) levels and non-alcoholic fatty liver disease (NAFLD) is controversial.

Objectives
We compared the...

Association between serum uric acid level and non-alcoholic fatty liver disease in Koreans

Article Category: Original article

Published Online: Feb 28, 2022

Page range: 15 - 22

DOI: https://doi.org/10.2478/abm-2022-0003

Keywords
gastroenterology, hepatic fibrosis, hepatic steatosis, non-alcoholic fatty liver disease, serum uric acid

© 2022 Huiyul Park et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Association between serum uric acid level and non-alcoholic fatty liver disease in Koreans

Article Category: Original article

Published Online: Feb 28, 2022

Page range: 15 - 22

DOI: https://doi.org/10.2478/abm-2022-0003

Keywordsgastroenterology, hepatic fibrosis, hepatic steatosis, non-alcoholic fatty liver disease, serum uric acid

© 2022 Huiyul Park et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
gastroenterology, hepatic fibrosis, hepatic steatosis, non-alcoholic fatty liver disease, serum uric acid