<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3><p>Oral lichen planus (OLP) is one of the most common diseases in the oral cavity and has a chronic inflammatory nature. The etiology of this disease remains unclear. OLP is more prevalent in women, but to our knowledge, no study yet evaluated estrogen levels in women with OLP.</p></sec>
<sec><h3>Objectives</h3><p>To determine the serum level of estrogen in female patients with OLP.</p></sec>
<sec><h3>Methods</h3><p>This case–control observational study was conducted in patients who were referred to the Department of Oral and Maxillofacial Medicine at the Tehran University of Medical Sciences. After clinical and histopathological confirmation of OLP diagnosis, and according to exclusion and inclusion criteria, 47 women with OLP and 47 healthy women (10 premenopausal and 37 postmenopausal) were included, as case and control groups, respectively. We obtained blood samples (5 mL) from each participant to measure the serum level of 17β-estradiol. Data were analyzed by Spearman rank correlation coefficients and a two-way analysis of variance with Bonferroni post hoc tests.</p></sec>
<sec><h3>Results</h3><p>Serum estrogen level in women with OLP was significantly higher than that in healthy women (<italic>P</italic> = 0.002), and it was also significantly higher in premenopausal women than postmenopausal women (<italic>P</italic> &lt; 0.001). The severity of OLP lesions correlated with estrogen level in postmenopausal women (<italic>r</italic> = 0.650; <italic>P</italic> &lt; 0.001); in premenopausal women (<italic>r</italic> = 0.618; <italic>P</italic> = 0.008), and in all women with OLP (<italic>r</italic> = 0.535; <italic>P</italic> &lt; 0.001).</p></sec>
<sec><h3>Conclusion</h3><p>OLP, like other autoimmune diseases, is affected by the serum level of sex hormones such as estrogen.</p></sec>
</abstract>

BackgroundOral lichen planus (OLP) is one of the most common diseases in the oral cavity and has a chronic inflammatory nature. The etiology of this disease remains unclear. OLP is more prevalent in women, but to our knowledge, no study yet evaluated estrogen levels in women with OLP.
ObjectivesTo determine the serum level of estrogen in female patients with OLP.
MethodsThis case–control observational study was conducted in patients who were referred to the Department of Oral and Maxillofacial Medicine at the Tehran University of Medical Sciences. After clinical and histopathological confirmation of OLP diagnosis, and according to exclusion and inclusion criteria, 47 women with OLP and 47 healthy women (10 premenopausal and 37 postmenopausal) were included, as case and control groups, respectively. We obtained blood samples (5 mL) from each participant to measure the serum level of 17β-estradiol. Data were analyzed by Spearman rank correlation coefficients and a two-way analysis of variance with Bonferroni post hoc tests.
ResultsSerum estrogen level in women with OLP was significantly higher than that in healthy women (P = 0.002), and it was also significantly higher in premenopausal women than postmenopausal women (P < 0.001). The severity of OLP lesions correlated with estrogen level in postmenopausal women (r = 0.650; P < 0.001); in premenopausal women (r = 0.618; P = 0.008), and in all women with OLP (r = 0.535; P < 0.001).
ConclusionOLP, like other autoimmune diseases, is affected by the serum level of sex hormones such as estrogen.

Serum level of estrogen in Iranian patients with oral lichen planus

Department of Oral and Maxillofacial Medicine, School of Dentistry

Department of Prosthetics, School of Dentistry

Shahid Beheshti University of Medical Science

Department of Physiology, School of Medicine

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Serum level of estrogen in Iranian patients with oral lichen planus"}

BackgroundOral lichen planus (OLP) is one of the most common diseases in the oral cavity and has a chronic inflammatory nature. The etiology of this disease...

	Healthy women	Women with OLP	P
Before menopause	58.9 ± 17.8 (n = 10)	119.8 ± 35.2 (n = 10)	0.002*
Post menopause	9.4 ± 3.2 (n = 37)	26.1 ± 6.3 (n = 37)	0.001*

	Before menopause	Post menopause	All
Healthy women	41.6 ± 5.4 (n = 10)	55.9 ± 4.0 (n = 37)	52.9 ± 7.3 (n = 47)
OLP	43.1 ± 3.4 (n = 10)	57.4 ± 4.9 (n = 37)	54.3 ± 7.5 (n = 47)
P	0.47	0.17	0.35

Serum level of estrogen in Iranian patients with oral lichen planus

Article Category: Brief communication (original)

Published Online: Jun 30, 2021

Page range: 145 - 150

DOI: https://doi.org/10.2478/abm-2021-0018

Keywords
estrogen, hormones, Iran, lichen planus, oral, menopause

© 2021 Narges Gholizadeh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Serum level of estrogen (pg/mL) in patients with OLP and healthy women (before and after menopause)

Age of participants (mean ± standard deviation) in years

Serum level of estrogen in Iranian patients with oral lichen planus

Article Category: Brief communication (original)

Published Online: Jun 30, 2021

Page range: 145 - 150

DOI: https://doi.org/10.2478/abm-2021-0018

Keywordsestrogen, hormones, Iran, lichen planus, oral, menopause

© 2021 Narges Gholizadeh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Serum level of estrogen (pg/mL) in patients with OLP and healthy women (before and after menopause)

Age of participants (mean ± standard deviation) in years

Keywords
estrogen, hormones, Iran, lichen planus, oral, menopause