<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida. In the 36<sup>th</sup> week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture. After induced delivery at term because of hypertension, repeated laboratory findings showed increased aspartate aminotransferase (AST) and <italic>alanine aminotransferase</italic> (ALT) and negative hepatitis C and B markers. The patient was subicteric at the time. Coagulation and complete blood count values were within the normal range. Nitrofurantoin therapy was discontinued. Abdominal ultrasound was normal with the exception of a slight hepatomegaly without any lesions, focal or diffuse. Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.</p></abstract>

This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida. In the 36th week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture. After induced delivery at term because of hypertension, repeated laboratory findings showed increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and negative hepatitis C and B markers. The patient was subicteric at the time. Coagulation and complete blood count values were within the normal range. Nitrofurantoin therapy was discontinued. Abdominal ultrasound was normal with the exception of a slight hepatomegaly without any lesions, focal or diffuse. Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.

Nitrofurantoin-Induced Acute Liver Damage in Pregnancy

Department of Obstetrics and Gynaecology, Sveti Duh General Hospital Zagreb, Zagreb, Croatia

Department of Obstetrics and Gynaecology, Polyclinic Sunce, Zagreb, Croatia

Archives of Industrial Hygiene and Toxicology

{"article-title":"Nitrofurantoin-Induced Acute Liver Damage in Pregnancy"}

This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida. In the 36th week of gestation, the patient was introduced...

Nitrofurantoin-Induced Acute Liver Damage in Pregnancy

Published Online: Sep 29, 2009

Page range: 357 - 361

DOI: https://doi.org/10.2478/10004-1254-60-2009-1940

Keywords
antibiotik, gravidne žene, hepatotoksičnost, terapija

This content is open access.

Nitrofurantoin-Induced Acute Liver Damage in Pregnancy

Published Online: Sep 29, 2009

Page range: 357 - 361

DOI: https://doi.org/10.2478/10004-1254-60-2009-1940

Keywordsantibiotik, gravidne žene, hepatotoksičnost, terapija

This content is open access.

Keywords
antibiotik, gravidne žene, hepatotoksičnost, terapija