<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">The combined influence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specific antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of influencing prostate function or metal metabolism. No significant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a significant increase in PSA with respect to an increase in blood lead, and a decrease in PSA with respect to an increase in intensity of alcohol consumption. The median and range values of blood lead concentration in the 57 men were 26.0 μg L-1 and (10.1 to 108.0) μg L-1, respectively. These results suggest that even a low-level environmental lead exposure, common for general populations worldwide, may contribute to the risk of prostate cancer in men. The influence of lead as well as cadmium, zinc, and selenium on prostate damage and PSA should be further investigated in relatively young men for the purpose of disease prevention.</abstract>

The combined influence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specific antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of influencing prostate function or metal metabolism. No significant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a significant increase in PSA with respect to an increase in blood lead, and a decrease in PSA with respect to an increase in intensity of alcohol consumption. The median and range values of blood lead concentration in the 57 men were 26.0 μg L-1 and (10.1 to 108.0) μg L-1, respectively. These results suggest that even a low-level environmental lead exposure, common for general populations worldwide, may contribute to the risk of prostate cancer in men. The influence of lead as well as cadmium, zinc, and selenium on prostate damage and PSA should be further investigated in relatively young men for the purpose of disease prevention.

Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

Institute for Medical Research and Occupational Health, Zagreb, Croatia

Diabetes, Endocrinology and Metabolic Diseases "Vuk Vrhovac", University Clinic, Zagreb, Croatia

Archives of Industrial Hygiene and Toxicology

The combined influence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on...

Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

Published Online: Mar 27, 2009

Page range: 69 - 78

DOI: https://doi.org/10.2478/10004-1254-60-2009-1901

Keywords
interakcija toksičnih i esencijalnih metala, čimbenici načina života, čovjekova izloženost olovu iz okoliša, izloženost kadmiju, oštećenje prostate

This content is open access.

Prostate-Specific Antigen (PSA) in Serum in Relation to Blood Lead Concentration and Alcohol Consumption in Men

Published Online: Mar 27, 2009

Page range: 69 - 78

DOI: https://doi.org/10.2478/10004-1254-60-2009-1901

Keywordsinterakcija toksičnih i esencijalnih metala, čimbenici načina života, čovjekova izloženost olovu iz okoliša, izloženost kadmiju, oštećenje prostate

This content is open access.

Keywords
interakcija toksičnih i esencijalnih metala, čimbenici načina života, čovjekova izloženost olovu iz okoliša, izloženost kadmiju, oštećenje prostate