Exhaled Breath Condensate pH in Adult Croatian Population Without Respiratory Disorders: How Healthy a Population Should Be to Provide Normative Data?

Koutsokera A, Loukides S, Gourgoulianis KI, Kostikas K. Biomarkers in the exhaled breath condensate of healthy adults: mapping the path towards reference values. Curr Med Chem 2008;15:620-30.10.2174/09298670878376976818336277Search in Google Scholar

Carpagnano GE, Foschino-Barbaro MP, Resta O, Gramiccioni E, Carpagnano F. Endothelin-1 is increased in the breath condensate of patients with non-small-cell lung cancer. Oncology 2004;66:180-4.10.1159/00007799215218307Search in Google Scholar

Gessner C, Kuhn H, Toepfer K, Hammerschmidt S, Schauer J, Wirtz H. Detection of p53 gene mutations in exhaled breath condensate of non-small cell lung cancer patients. Lung Cancer 2004;43:215-22.10.1016/j.lungcan.2003.08.03414739043Search in Google Scholar

Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden WJ, Corradi M, Dekhuijzen R, Dweik RA, Dwyer T, Effros R, Erzurum S, Gaston B, Gessner C, Greening A, Ho LP, Hohlfeld J, Jobsis Q, Laskowski D, Loukides S, Marlin D, Montuschi P, Olin AC, Redington AE, Reinhold P, van Rensen EL, Rubinstein I, Silkoff P, Toren K, Vass G, Vogelberg C, Wirtz H. ATS/ERS Task force on exhaled breath condensate. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005;26:523-48.10.1183/09031936.05.0002970516135737Search in Google Scholar

Mutti A, Corradi M. Recent developments in human biomonitoring: non-invasive assessment of target tissue dose and effects of pneumotoxic metals. Med Lav 2006;97:199-206.Search in Google Scholar

Goldoni M, Catalani S, De Palma G, Manini P, Acampa O, Corradi M, Bergonzi R, Apostoli P, Mutti A. Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten. Environ Health Perspect 2004;112:1293-8.10.1289/ehp.7108124751915345342Search in Google Scholar

Maniscalco M, De Laurentiis G, Pentella C, Mormile M, Sanduzzi A, Carratu P, Sofia M. Exhaled breath condensate as matrix for toluene detection: A preliminary study. Biomarkers 2006;11:233-40.10.1080/1354750060069299216760132Search in Google Scholar

Hunt J. Exhaled breath condensate pH assays. Immunol Allergy Clin North Am 2007;27:597-606.10.1016/j.iac.2007.09.006285845217996578Search in Google Scholar

Prieto L, Ferrer A, Palop J, Domenech J, Llusar R, Rojas R. Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices. Respir Med 2007;101:1715-20.10.1016/j.rmed.2007.02.02317481878Search in Google Scholar

Kullmann T, Barta I, Lazar Z, Szili B, Barat E, Valyon M, Kollai M, Horvath I. Exhaled breath condensate pH standardised for CO₂ partial pressure. Eur Respir J 2007;29:496-501.10.1183/09031936.0008400617079255Search in Google Scholar

Effros RM, Casaburi R, Su J, Dunning M, Torday J, Biller J, Shaker R. The effects of volatile salivary acids and bases on exhaled breath condensate pH. Am J Respir Crit Care Med 2006;173:386-92.10.1164/rccm.200507-1059OC266294016284109Search in Google Scholar

Leung TF, Li CY, Yung E, Liu EK, Lam CW, Wong GW. Clinical and technical factors affecting pH and other biomarkers in exhaled breath condensate. Pediatr Pulmonol 2006;41:87-94.10.1002/ppul.2029616292777Search in Google Scholar

Paget-Brown AO, Ngamtrakulpanit L, Smith A, Bunyan D, Hom S, Nguyen A, Hunt JF. Normative data for pH of exhaled breath condensate. Chest 2006;129:426-30.10.1378/chest.129.2.42616478862Search in Google Scholar

Tate S, MacGregor G, Davis M, Innes JA, Greening AP. Airways in cystic fibrosis are acidified: detection by exhaled breath condensate. Thorax 2002;57:926-9.10.1136/thorax.57.11.926174623312403872Search in Google Scholar

McCafferty JB, Bradshaw TA, Tate S, Greening AP, Innes JA. Effects of breathing pattern and inspired air conditions on breath condensate volume, pH, nitrite, and protein concentrations. Thorax 2004;59:694-8.10.1136/thx.2003.016949174711415282391Search in Google Scholar

Ojoo JC, Mulrennan SA, Kastelik JA, Morice AH, Redington AE. Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis. Thorax 2005;60:22-6.10.1136/thx.2003.017327174715415618578Search in Google Scholar

Bloemen K, Lissens G, Desager K, Schoeters G. Determinants of variability of protein content, volume and pH of exhaled breath condensate. Respir Med 2007;101:1331-7.10.1016/j.rmed.2006.10.00817125983Search in Google Scholar

Niimi A, Nguyen LT, Usmani O, Mann B, Chung KF. Reduced pH and chloride levels in exhaled breath condensate of patients with chronic cough. Thorax 2004;59:608-12.10.1136/thx.2003.012906174707915223872Search in Google Scholar

Brooks SM, Haight RR, Gordon RL. Age does not affect airway pH and ammonia as determined by exhaled breath measurements. Lung 2006;184:195-200.10.1007/s00408-005-2580-117006745Search in Google Scholar

Hauswirth DW, Sundy JS, Mervin-Blake S, Fernandez CA, Patch KB, Alexander KM, Allgood S, McNair PD, Levesque MC. Normative values for exhaled breath condensate pH and its relationship to exhaled nitric oxide in healthy African Americans. J Allergy Clin Immunol 2008;122:101-6.10.1016/j.jaci.2008.03.02418472151Search in Google Scholar

Hunt JF, Fang KZ, Malik R, Snyder A, Malhotra N, Platts-Mills TAE Gaston B. Endogenous airway acidification - Implications for asthma pathophysiology. Am J Respir Crit Care Med 2000;161:694-9.10.1164/ajrccm.161.3.991100510712309Search in Google Scholar

Kostikas K, Papatheodorou G, Ganas K, Psathakis K, Panagou P, Loukides S. pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 2002;165:1364-70.10.1164/rccm.200111-068OCSearch in Google Scholar

Gessner C, Hammerschmidt S, Kuhn H, Seyfarth HJ, Sack U, Engelmann L, Schauer J, Wirtz H. Exhaled breath condensate acidification in acute lung injury. Respir Med 2003;97:1188-94.10.1016/S0954-6111(03)00225-7Search in Google Scholar

Vaughan J, Ngamtrakulpanit L, Pajewski TN, Turner R, Nguyen TA, Smith A, Urban P, Hom S, Gaston B, Hunt J. Exhaled breath condensate pH is a robust and reproducible assay of airway acidity. Eur Respir J 2003;22:889-94.10.1183/09031936.03.0003880314680074Search in Google Scholar

Wells K, Vaughan J, Pajewski TN, Hom S, Ngamtrakulpanit L, Smith A, Nguyen A, Turner R, Hunt J. Exhaled breath condensate pH assays are not influenced by oral ammonia. Thorax 2005;60:27-31.10.1136/thx.2003.020602174714715618579Search in Google Scholar

Borrill Z, Starkey C, Vestbo J, Singh D. Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease. Eur Respir J 2005;25:269-74.10.1183/09031936.05.0008580415684290Search in Google Scholar

Carpagnano GE, Foschino Barbaro MP, Cagnazzo M, Di Gioia G, Giliberti T, Di Matteo C, Resta O. Use of exhaled breath condensate in the study of airway inflammation after hypertonic saline solution challenge. Chest 2005;128:3159-66.10.1378/chest.128.5.315916304257Search in Google Scholar

Carpagnano GE, Foschino Barbaro MP, Resta O, Gramiccioni E, Valerio NV, Bracciale P, Valerio G. Exhaled markers in the monitoring of airways inflammation and its response to steroid's treatment in mild persistent asthma. Eur J Pharmacol 2005;519:175-81.10.1016/j.ejphar.2005.06.03416122732Search in Google Scholar

Soyer OU, Dizdar EA, Keskin O, Lilly C, Kalayci O. Comparison of two methods for exhaled breath condensate collection. Allergy 2006;61:1016-8.10.1111/j.1398-9995.2006.01064.x16867057Search in Google Scholar

Riediker M, Danuser B. Exhaled breath condensate pH is increased after moderate exercise. J Aerosol Med 2007;20:13-8.10.1089/jam.2006.056717388749Search in Google Scholar

Hoffmeyer F, Harth V, Merget R, Goldscheid N, Heinze E, Degens P, Pesch B, Buenger J, Bruening T, Raulf-Heimsoth M. Exhaled breath condensate analysis: evaluation of a methodological setting for epidemiological field studies. J Physiol Pharmacol 2007;58(Suppl 5):289-98.Search in Google Scholar

Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993;16:5-40.10.1183/09041950.005s169324576915Search in Google Scholar

Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL, Spector SL, Townley RG. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 1975;56:323-7.10.1016/0091-6749(75)90107-4Search in Google Scholar

Aberer W, Kranke B. Measurement of IgE antibodies using liquid allergens — an inter-method and inter-laboratory quality assessment. Wien Klin Wochenschr 2002;114:929-37.Search in Google Scholar

Dreborg S, Frew A. Position paper. Allergen standardisation and skin tests. Allergy 1993;48(Suppl 14):49-82.10.1111/j.1398-9995.1993.tb04756.xSearch in Google Scholar

Borrill ZL, Roy K, Singh D. Exhaled breath condensate biomarkers in COPD. Eur Resp J 2008;32:472-86.10.1183/09031936.00116107Search in Google Scholar

Carpagnano GE, Kharitonov SA, Foschino-Barbaro MP, Resta O, Gramiccioni E, Barnes PJ. Increased inflammatory markers in the exhaled breath condensate of cigarette smokers. Eur Respir J 2003;21:589-93.10.1183/09031936.03.00022203Search in Google Scholar

Montuschi P, Collins JV, Ciabattoni G, Lazzeri N, Corradi M, Kharitonov SA, Barnes PJ. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med 2000;162:1175-7.10.1164/ajrccm.162.3.2001063Search in Google Scholar

Nowak D, Kalucka S, Białasiewicz P, Król M. Exhalation of H2O2 and thiobarbituric acid reactive substances (TBARs) by healthy subjects. Free Radic Biol Med 2001;30:178-86.10.1016/S0891-5849(00)00457-3Search in Google Scholar

Do R, Bartlett KH, Chu W, Dimich-Ward H, Kennedy SM. Within- and between-person variability of exhaled breath condensate pH and NH4+ in never and current smokers. Resp Med 2008;102:457-63.10.1016/j.rmed.2007.10.00217988849Search in Google Scholar

Boulet LP, Lemiere C, Archambault F, Carrier G, Descary MC, Deschesnes F. Smoking and asthma: clinical and radiologic features, lung function, and airway inflammation. Chest 2006;129:661-8.10.1378/chest.129.3.66116537865Search in Google Scholar

Effros RM, Dunning MB 3rd, Biller J, Shaker R. The promise and perils of exhaled breath condensates. Am J Physiol Lung Cell Mol Physiol 2004;287:L1073-80.10.1152/ajplung.00069.200415531756Search in Google Scholar

Brunetti L, Francavilla R, Tesse R, Strippoli A, Polimeno L, Loforese A, Miniello VL, Armenio L. Exhaled breath condensate pH measurement in children with asthma, allergic rhinitis and atopic dermatitis. Pediatr Allergy Immunol 2006;17:422-7.10.1111/j.1399-3038.2006.00426.x16925687Search in Google Scholar

Profita M, La Grutta S, Carpagnano E, Riccobono L, Di Giorgi R, Bonanno A, Pace E, Bonsignore G, Bousquet J, Vignola AM, Gjomarkaj M. Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. J Allergy Clin Immunol 2006;118:1068-74.10.1016/j.jaci.2006.07.02817088131Search in Google Scholar

Nicolaou NC, Lowe LA, Murray CS, Woodcock A, Simpson A, Ćustović A. Exhaled breath condensate pH and childhood asthma: unselected birth cohort study. Am J Respir Crit Care Med 2006;174:254-9.10.1164/rccm.200601-140OC16675782Search in Google Scholar