Open Access

Effectiveness and safety of dexamphetamine sulfate (Attentin®) in the routine treatment of children and adolescents with ADHD: results from a 12-month non-interventional study


Cite

Thomas R, Sanders S, Doust J, Beller E, Glasziou P. Prevalence of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Pediatrics 2015;135(4):e994-1001. Thomas R Sanders S Doust J Beller E Glasziou P . Prevalence of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis . Pediatrics 2015 ; 135 ( 4 ): e994 - 1001 . Search in Google Scholar

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC, American Psychiatric Association; 2013. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders . 5th ed. Washington, DC , American Psychiatric Association ; 2013 . Search in Google Scholar

World Health Organization. International Classification of Diseases (ICD-10). 1992. World Health Organization . International Classification of Diseases (ICD-10) . 1992 . Search in Google Scholar

AWMF. Langfassung der interdisziplinären evidenz- und konsensbasierten (S3) Leitlinie “Aufmerksamkeitsdefizit- / Hyperaktivitätsstörung (ADHS) im Kindes-, Jugend- und Erwachsenenalter”. Registernummer 028 - 045. [Long version of the interdisciplinary evidence and consensus-based (S3) guideline “Attention Deficit / Hyperactivity Disorder (ADHD) in children, adolescents and adults]; 2018 [Available from: https://www.awmf.org/leitlinien/detail/ll/028-045.html AWMF . Langfassung der interdisziplinären evidenz- und konsensbasierten (S3) Leitlinie “Aufmerksamkeitsdefizit- / Hyperaktivitätsstörung (ADHS) im Kindes-, Jugend- und Erwachsenenalter” . Registernummer 028 - 045. [Long version of the interdisciplinary evidence and consensus-based (S3) guideline “Attention Deficit / Hyperactivity Disorder (ADHD) in children, adolescents and adults] ; 2018 [Available from: https://www.awmf.org/leitlinien/detail/ll/028-045.html Search in Google Scholar

Wolraich ML, Hagan JF, Allan C, Chan E, Davison D, Earls M, et al. Clinical practice guideline for the diagnosis, evaluation, and treatment of Attention-Deficit/Hyperactivity Disorder in children and adolescents. Pediatrics 2019;144(4):e20192528. Wolraich ML Hagan JF Allan C Chan E Davison D Earls M Clinical practice guideline for the diagnosis, evaluation, and treatment of Attention-Deficit/Hyperactivity Disorder in children and adolescents . Pediatrics 2019 ; 144 ( 4 ): e20192528 . Search in Google Scholar

CADDRA. Canadian ADHD Practice Guidelines; Fourth Edition. Toronto ON: CADDRA; 2018. CADDRA . Canadian ADHD Practice Guidelines ; Fourth Edition . Toronto ON : CADDRA ; 2018 . Search in Google Scholar

National Institute for Health and Care Excellence. Attention deficit hyperactivity disorder: diagnosis and management. NICE guideline [NG87]. 2018 [Available from: nice.org.uk/guidance/ng87]. National Institute for Health and Care Excellence. Attention deficit hyperactivity disorder: diagnosis and management . NICE guideline [NG87] . 2018 [Available from: nice.org.uk/guidance/ng87 ]. Search in Google Scholar

Pliszka SR. Pharmacologic treatment of attention-deficit/hyperactivity disorder: efficacy, safety and mechanisms of action. Neuropsychol Rev 2007;17(1):61-72. Pliszka SR . Pharmacologic treatment of attention-deficit/hyperactivity disorder: efficacy, safety and mechanisms of action . Neuropsychol Rev 2007 ; 17 ( 1 ): 61 - 72 . Search in Google Scholar

Punja S, Shamseer L, Hartling L, Urichuk L, Vandermeer B, Nikles J, et al. Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents. Cochrane Database Syst Rev 2016;2:CD009996. Punja S Shamseer L Hartling L Urichuk L Vandermeer B Nikles J Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents . Cochrane Database Syst Rev 2016 ; 2 : CD009996 . Search in Google Scholar

Coghill DR, Banaschewski T, Soutullo C, Cottingham MG, Zuddas A. Systematic review of quality of life and functional outcomes in randomized placebo-controlled studies of medications for attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry 2017;26(11):1283-307. Coghill DR Banaschewski T Soutullo C Cottingham MG Zuddas A . Systematic review of quality of life and functional outcomes in randomized placebo-controlled studies of medications for attention-deficit/hyperactivity disorder . Eur Child Adolesc Psychiatry 2017 ; 26 ( 11 ): 1283 - 307 . Search in Google Scholar

Boland H, DiSalvo M, Fried R, Woodworth KY, Wilens T, Faraone SV, et al. A literature review and meta-analysis on the effects of ADHD medications on functional outcomes. J Psychiatr Res 2020;123:21-30. Boland H DiSalvo M Fried R Woodworth KY Wilens T Faraone SV A literature review and meta-analysis on the effects of ADHD medications on functional outcomes . J Psychiatr Res 2020 ; 123 : 21 - 30 . Search in Google Scholar

Faraone SV, Buitelaar J. Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. Eur Child Adolesc Psychiatry 2010;19(4):353-64. Faraone SV Buitelaar J . Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis . Eur Child Adolesc Psychiatry 2010 ; 19 ( 4 ): 353 - 64 . Search in Google Scholar

Faraone SV. The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities. Neurosci Biobehav Rev 2018;87:255-70. Faraone SV . The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities . Neurosci Biobehav Rev 2018 ; 87 : 255 - 70 . Search in Google Scholar

Easton N, Steward C, Marshall F, Fone K, Marsden C. Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain. Neuropharmacology 2007;52(2):405-14. Easton N Steward C Marshall F Fone K Marsden C . Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain . Neuropharmacology 2007 ; 52 ( 2 ): 405 - 14 . Search in Google Scholar

Riddle EL, Hanson GR, Fleckenstein AE. Therapeutic doses of amphetamine and methylphenidate selectively redistribute the vesicular monoamine transporter-2. Eur J Pharmacol 2007;571(1):25-8. Riddle EL Hanson GR Fleckenstein AE . Therapeutic doses of amphetamine and methylphenidate selectively redistribute the vesicular monoamine transporter-2 . Eur J Pharmacol 2007 ; 571 ( 1 ): 25 - 8 . Search in Google Scholar

Robinson JB. Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors. Enantiomers of amphetamine, N-methylamphetamine and deprenyl. Biochem Pharmacol 1985;34(23):4105-8. Robinson JB . Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors. Enantiomers of amphetamine, N-methylamphetamine and deprenyl . Biochem Pharmacol 1985 ; 34 ( 23 ): 4105 - 8 . Search in Google Scholar

Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A. Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci 1995;15(5 Pt 2):4102-8. Sulzer D Chen TK Lau YY Kristensen H Rayport S Ewing A . Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport . J Neurosci 1995 ; 15 (5 Pt 2): 4102 - 8 . Search in Google Scholar

Steingard R, Taskiran S, Connor DF, Markowitz JS, Stein MA. New formulations of stimulants: an update for clinicians. J Child Adolesc Psychopharmacol 2019;29(5):324-39. Steingard R Taskiran S Connor DF Markowitz JS Stein MA . New formulations of stimulants: an update for clinicians . J Child Adolesc Psychopharmacol 2019 ; 29 ( 5 ): 324 - 39 . Search in Google Scholar

MEDICE Arzneimittel Pütter GmbH & Co KG. Attentin 5/10/20 mg SmPC. 06/2020. MEDICE Arzneimittel Pütter GmbH & Co KG. Attentin 5/10/20 mg SmPC. 06/2020 . Search in Google Scholar

Elia J, Borcherding BG, Rapoport JL, Keysor CS. Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders? Psychiatry Res 1991;36(2):141-55. Elia J Borcherding BG Rapoport JL Keysor CS . Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders? Psychiatry Res 1991 ; 36 ( 2 ): 141 - 55 . Search in Google Scholar

Sharp WS, Walter JM, Marsh WL, Ritchie GF, Hamburger SD, Castellanos FX. ADHD in girls: clinical comparability of a research sample. J Am Acad Child Adolesc Psychiatry 1999;38(1):40-7. Sharp WS Walter JM Marsh WL Ritchie GF Hamburger SD Castellanos FX . ADHD in girls: clinical comparability of a research sample . J Am Acad Child Adolesc Psychiatry 1999 ; 38 ( 1 ): 40 - 7 . Search in Google Scholar

Elia J, Welsh PA, Gullotta CS, Rapoport JL. Classroom academic performance: improvement with both methylphenidate and dextroamphetamine in ADHD boys. J Child Psychol Psychiatry 1993;34(5):785-804. Elia J Welsh PA Gullotta CS Rapoport JL . Classroom academic performance: improvement with both methylphenidate and dextroamphetamine in ADHD boys . J Child Psychol Psychiatry 1993 ; 34 ( 5 ): 785 - 804 . Search in Google Scholar

Pelham WE, Jr., Greenslade KE, Vodde-Hamilton M, Murphy DA, Greenstein JJ, Gnagy EM, et al. Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline. Pediatrics 1990;86(2):226-37. Pelham WE Jr. Greenslade KE Vodde-Hamilton M Murphy DA Greenstein JJ Gnagy EM Relative efficacy of long-acting stimulants on children with attention deficit-hyperactivity disorder: a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline . Pediatrics 1990 ; 86 ( 2 ): 226 - 37 . Search in Google Scholar

James RS, Sharp WS, Bastain TM, Lee PP, Walter JM, Czarnolewski M, et al. Double-blind, placebo-controlled study of single-dose amphetamine formulations in ADHD. J Am Acad Child Adolesc Psychiatry 2001;40(11):1268-76. James RS Sharp WS Bastain TM Lee PP Walter JM Czarnolewski M Double-blind, placebo-controlled study of single-dose amphetamine formulations in ADHD . J Am Acad Child Adolesc Psychiatry 2001 ; 40 ( 11 ): 1268 - 76 . Search in Google Scholar

Gillberg C, Melander H, von Knorring AL, Janols LO, Thernlund G, Hagglof B, et al. Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial. Arch Gen Psychiatry 1997;54(9):857-64. Gillberg C Melander H von Knorring AL Janols LO Thernlund G Hagglof B Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. A randomized, double-blind, placebo-controlled trial . Arch Gen Psychiatry 1997 ; 54 ( 9 ): 857 - 64 . Search in Google Scholar

Ramtvedt BE, Roinas E, Aabech HS, Sundet KS. Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials. J Child Adolesc Psychopharmacol 2013;23(9):597-604. Ramtvedt BE Roinas E Aabech HS Sundet KS . Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials . J Child Adolesc Psychopharmacol 2013 ; 23 ( 9 ): 597 - 604 . Search in Google Scholar

Cortese S, Adamo N, Del Giovane C, Mohr-Jensen C, Hayes AJ, Carucci S, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry 2018;5(9):727-38. Cortese S Adamo N Del Giovane C Mohr-Jensen C Hayes AJ Carucci S Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis . Lancet Psychiatry 2018 ; 5 ( 9 ): 727 - 38 . Search in Google Scholar

Hodgkins P, Shaw M, Coghill D, Hechtman L. Amfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment options. Eur Child Adolesc Psychiatry 2012;21(9):477-92. Hodgkins P Shaw M Coghill D Hechtman L . Amfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment options . Eur Child Adolesc Psychiatry 2012 ; 21 ( 9 ): 477 - 92 . Search in Google Scholar

Greenhill LL, Pliszka S, Dulcan MK, Bernet W, Arnold V, Beitchman J, et al. Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 2002;41(2 Suppl):26S-49S. Greenhill LL Pliszka S Dulcan MK Bernet W Arnold V Beitchman J Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults . J Am Acad Child Adolesc Psychiatry 2002 ; 41 ( 2 Suppl ): 26S - 49S . Search in Google Scholar

Cortese S, Holtmann M, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, et al. Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. J Child Psychol Psychiatry 2013;54(3):227-46. Cortese S Holtmann M Banaschewski T Buitelaar J Coghill D Danckaerts M Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents . J Child Psychol Psychiatry 2013 ; 54 ( 3 ): 227 - 46 . Search in Google Scholar

Blonde L, Khunti K, Harris SB, Meizinger C, Skolnik NS. Interpretation and impact of real-world clinical data for the practicing clinician. Adv Ther 2018;35(11):1763-1774. Blonde L Khunti K Harris SB Meizinger C Skolnik NS . Interpretation and impact of real-world clinical data for the practicing clinician . Adv Ther 2018 ; 35 ( 11 ): 1763 - 1774 . Search in Google Scholar

Zhang S, Faries DE, Vowles M, Michelson D. ADHD Rating Scale IV: psychometric properties from a multinational study as a clinician-administered instrument. Int J Methods Psychiatr Res 2005;14(4):186-201. Zhang S Faries DE Vowles M Michelson D . ADHD Rating Scale IV: psychometric properties from a multinational study as a clinician-administered instrument . Int J Methods Psychiatr Res 2005 ; 14 ( 4 ): 186 - 201 . Search in Google Scholar

R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/; 2020. R Core Team. R: A language and environment for statistical computing . R Foundation for Statistical Computing , Vienna, Austria . URL https://www.R-project.org/ ; 2020 . Search in Google Scholar

Wickham H, Miller E. Import and Export 'SPSS', 'Stata' and 'SAS' Files. R package version 2.3.1., Package ‘haven’ https://CRAN.R-project.org/package=haven; 2020. Wickham H Miller E . Import and Export 'SPSS', 'Stata' and 'SAS' Files . R package version 2.3.1., Package ‘haven’ https://CRAN.R-project.org/package=haven ; 2020 . Search in Google Scholar

McLeod M, Laubscher T, Regier L, Jensen B. Taking the stress out of individualizing ADHD drug therapy. Can Fam Physician 2009;55(9):895-8. McLeod M Laubscher T Regier L Jensen B . Taking the stress out of individualizing ADHD drug therapy . Can Fam Physician 2009 ; 55 ( 9 ): 895 - 8 . Search in Google Scholar

Greydanus DE, Sloane MA, Rappley MD. Psychopharmacology of ADHD in adolescents. Adolesc Med 2002;13(3):599-624. Greydanus DE Sloane MA Rappley MD . Psychopharmacology of ADHD in adolescents . Adolesc Med 2002 ; 13 ( 3 ): 599 - 624 . Search in Google Scholar

Daughton JM, Kratochvil CJ. Review of ADHD pharmacotherapies: advantages, disadvantages, and clinical pearls. J Am Acad Child Adolesc Psychiatry 2009;48(3):240-8. Daughton JM Kratochvil CJ . Review of ADHD pharmacotherapies: advantages, disadvantages, and clinical pearls . J Am Acad Child Adolesc Psychiatry 2009 ; 48 ( 3 ): 240 - 8 . Search in Google Scholar

Brown GL, Hunt RD, Ebert MH, Bunney WE, Jr., Kopin IJ. Plasma levels of d-amphetamine in hyperactive children. Serial behavior and motor responses. Psychopharmacology (Berl) 1979;62(2):133-40. Brown GL Hunt RD Ebert MH Bunney WE Jr. Kopin IJ . Plasma levels of d-amphetamine in hyperactive children. Serial behavior and motor responses . Psychopharmacology (Berl) 1979 ; 62 ( 2 ): 133 - 40 . Search in Google Scholar

Huss M, Duhan P, Gandhi P, Chen CW, Spannhuth C, Kumar V. Methylphenidate dose optimization for ADHD treatment: review of safety, efficacy, and clinical necessity. Neuropsychiatr Dis Treat 2017;13:1741-51. Huss M Duhan P Gandhi P Chen CW Spannhuth C Kumar V . Methylphenidate dose optimization for ADHD treatment: review of safety, efficacy, and clinical necessity . Neuropsychiatr Dis Treat 2017 ; 13 : 1741 - 51 . Search in Google Scholar

Faraone SV, Biederman J, Morley CP, Spencer TJ. Effect of stimulants on height and weight: a review of the literature. J Am Acad Child Adolesc Psychiatry 2008;47(9):994-1009. Faraone SV Biederman J Morley CP Spencer TJ . Effect of stimulants on height and weight: a review of the literature . J Am Acad Child Adolesc Psychiatry 2008 ; 47 ( 9 ): 994 - 1009 . Search in Google Scholar

Hennissen L, Bakker MJ, Banaschewski T, Carucci S, Coghill D, Danckaerts M, et al. Cardiovascular effects of stimulant and non-stimulant medication for children and adolescents with ADHD: a systematic review and meta-analysis of trials of methylphenidate, amphetamines and atomoxetine. CNS drugs 2017;31(3):199-215. Hennissen L Bakker MJ Banaschewski T Carucci S Coghill D Danckaerts M Cardiovascular effects of stimulant and non-stimulant medication for children and adolescents with ADHD: a systematic review and meta-analysis of trials of methylphenidate, amphetamines and atomoxetine . CNS drugs 2017 ; 31 ( 3 ): 199 - 215 . Search in Google Scholar

Cortese S. Pharmacologic treatment of Attention Deficit– Hyperactivity Disorder. N Engl J Med 2020;383(11):1050-6. Cortese S . Pharmacologic treatment of Attention Deficit– Hyperactivity Disorder . N Engl J Med 2020 ; 383 ( 11 ): 1050 - 6 . Search in Google Scholar

Mick E, McManus DD, Goldberg RJ. Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults. Eur Neuropsychopharmacol 2013;23(6):534-41. Mick E McManus DD Goldberg RJ . Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults . Eur Neuropsychopharmacol 2013 ; 23 ( 6 ): 534 - 41 . Search in Google Scholar

Hammerness PG, Perrin JM, Shelley-Abrahamson R, Wilens TE. Cardiovascular risk of stimulant treatment in pediatric attention-deficit/hyperactivity disorder: update and clinical recommendations. J Am Acad Child Adolesc Psychiatry 2011;50(10):978-90. Hammerness PG Perrin JM Shelley-Abrahamson R Wilens TE . Cardiovascular risk of stimulant treatment in pediatric attention-deficit/hyperactivity disorder: update and clinical recommendations . J Am Acad Child Adolesc Psychiatry 2011 ; 50 ( 10 ): 978 - 90 . Search in Google Scholar

Liu H, Feng W, Zhang D. Association of ADHD medications with the risk of cardiovascular diseases: a meta-analysis. Eur Child Adolesc Psychiatry 2019;28(10):1283-93. Liu H Feng W Zhang D . Association of ADHD medications with the risk of cardiovascular diseases: a meta-analysis . Eur Child Adolesc Psychiatry 2019 ; 28 ( 10 ): 1283 - 93 . Search in Google Scholar

Cortese S, Coghill D. Twenty years of research on attention-deficit/hyperactivity disorder (ADHD): looking back, looking forward. Evid Based Ment Health 2018;21(4):173-6. Cortese S Coghill D . Twenty years of research on attention-deficit/hyperactivity disorder (ADHD): looking back, looking forward . Evid Based Ment Health 2018 ; 21 ( 4 ): 173 - 6 . Search in Google Scholar

eISSN:
2245-8875
Language:
English
Publication timeframe:
Volume Open
Journal Subjects:
Medicine, Basic Medical Science, other