<abstract xmlns="http://www.w3.org/1999/xhtml"><p><italic>Proteus</italic> spp. is an etiological factor of urinary tract and bloodstream infections. The aim of this study was the retrospective analysis of susceptibility of <italic>Proteus</italic> spp. strains isolated from bloodstream infections (BSIs) as well as similarity evaluation of the strains isolated from different clinical samples. <italic>Proteus</italic> spp. strains were isolated in 2009–2017 from hospital patients. Identification was based on the colony’s morphology and biochemical or MALDI-TOF MS analyzes. The antibiotic susceptibility test was done using the diffusion method. Biofilm formation was evaluated with microplate method using TTC. Bacteremia caused by <italic>Proteus</italic> spp. was found in 97 patients, mainly secondary to urinary tract infection. Most of the strains were susceptible to piperacillin with tazobactam (95.9%) and amikacin (86.7%). Elderly patients have a higher risk of mortality after BSIs caused by <italic>Proteus</italic> spp. A detailed analysis was made for randomly chosen 26 strains isolated from 11 patients with <italic>Proteus mirabilis</italic> bacteremia. Using PFGE, we found that 10 (90.9%) isolates, collected from different clinical specimens of the same patient, were genetically identical.</p></abstract>

Proteus spp. is an etiological factor of urinary tract and bloodstream infections. The aim of this study was the retrospective analysis of susceptibility of Proteus spp. strains isolated from bloodstream infections (BSIs) as well as similarity evaluation of the strains isolated from different clinical samples. Proteus spp. strains were isolated in 2009–2017 from hospital patients. Identification was based on the colony’s morphology and biochemical or MALDI-TOF MS analyzes. The antibiotic susceptibility test was done using the diffusion method. Biofilm formation was evaluated with microplate method using TTC. Bacteremia caused by Proteus spp. was found in 97 patients, mainly secondary to urinary tract infection. Most of the strains were susceptible to piperacillin with tazobactam (95.9%) and amikacin (86.7%). Elderly patients have a higher risk of mortality after BSIs caused by Proteus spp. A detailed analysis was made for randomly chosen 26 strains isolated from 11 patients with Proteus mirabilis bacteremia. Using PFGE, we found that 10 (90.9%) isolates, collected from different clinical specimens of the same patient, were genetically identical.

Primary and Secondary Bacteremia Caused by <italic>Proteus</italic> spp.: Epidemiology, Strains Susceptibility and Biofilm Formation

Polish Journal of Microbiology

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Primary and Secondary Bacteremia Caused by  spp.: Epidemiology, Strains Susceptibility and Biofilm Formation

Proteus spp. is an etiological factor of urinary tract and bloodstream infections. The aim of this study was the retrospective analysis of susceptibility of...

Primary and Secondary Bacteremia Caused by Proteus spp.: Epidemiology, Strains Susceptibility and Biofilm Formation

Article Category: original-paper

Published Online: Dec 10, 2018

Page range: 471 - 478

Received: Jul 03, 2018

Accepted: Sep 06, 2018

DOI: https://doi.org/10.21307/pjm-2018-055

Keywords
antimicrobial susceptibility, bacteremia, biofilm, spp.

© 2018 Joanna Kwiecińska-Piróg et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Primary and Secondary Bacteremia Caused by Proteus spp.: Epidemiology, Strains Susceptibility and Biofilm Formation

Article Category: original-paper

Published Online: Dec 10, 2018

Page range: 471 - 478

Received: Jul 03, 2018

Accepted: Sep 06, 2018

DOI: https://doi.org/10.21307/pjm-2018-055

Keywordsantimicrobial susceptibility, bacteremia, biofilm, spp.

© 2018 Joanna Kwiecińska-Piróg et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
antimicrobial susceptibility, bacteremia, biofilm, spp.