This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Appleton R.E., Rainford N.E.A., Gamble C., Messahei S., Humphreys A., Hickey H. et al. Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT. Health Technology Assessment, 2020, 2020 (58), 1–96. doi: 10.3310/hta24580AppletonR.E.RainfordN.E.A.GambleC.MessaheiS.HumphreysA.HickeyH.Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT. , 2020, 2020 (58), 1–96. doi: 10.3310/hta24580Open DOISearch in Google Scholar
Arrigo A., Raiteri U., Ardizzone G. Levetiracetam monotherapy for treatment of partial status epilepticus in a patient following a liver transplant. Epilepsia, 2004, 2004 (Suppl. 3), 145.ArrigoA.RaiteriU.ArdizzoneG.Levetiracetam monotherapy for treatment of partial status epilepticus in a patient following a liver transplant. , 2004, 2004 (Suppl. 3), 145.Search in Google Scholar
Chakravarthi S., Goyal M.K., Modi M., Bhalla A., Singh P. Levetriacetam versus phenytoin in management of status epilepticus. Journal of Clinical Neuroscience, 2015, 2015, 959–963. doi: 10.1016/j.jocn.2014.12.013.ChakravarthiS.GoyalM.K.ModiM.BhallaA.SinghP.Levetriacetam versus phenytoin in management of status epilepticus. , 2015, 2015, 959–963. doi: 10.1016/j.jocn.2014.12.013.Open DOISearch in Google Scholar
Chamberlain J.M., Kapur J., Shinnar S., Elm J., Holsti M., Babcock L. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomized controlled trial. Lancet, 2020, 2020 (10231), 1217–1224. doi: 10.1017/S01406736(20)30611–5.ChamberlainJ.M.KapurJ.ShinnarS.ElmJ.HolstiM.BabcockL.Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomized controlled trial. , 2020, 2020 (10231), 1217–1224. doi: 10.1017/S01406736(20)30611–5.Open DOISearch in Google Scholar
Dalziel S.R., Borland M.L., Furyk J., Bonisch M., Neutze J., Donath S. et al. Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (Con-SEPT): an open-labe, multicentre, randomized controlled trial. Lancet, 2019, 2019 (10186): 2135–2145. doi 10.1016/S01406736(19)30722–6DalzielS.R.BorlandM.L.FurykJ.BonischM.NeutzeJ.DonathS.Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (Con-SEPT): an open-labe, multicentre, randomized controlled trial. , 2019, 2019 (10186): 2135–2145. doi 10.1016/S01406736(19)30722–6Open DOISearch in Google Scholar
Gujjar A.R., Nandhagopal R., Jacob P.C., Al-Hashim A., Al-Amrani K., Ganguly S.S. et al. Intravenous levetiracetam vs phenytoin for status epilepticus and cluster seizures: A prospective, randomized study. Seizure: European Journal of Epileptology, 2017, 2017, 8–12. doi: 10.1016/j.seizure.2017.05.001GujjarA.R.NandhagopalR.JacobP.C.Al-HashimA.Al-AmraniK.GangulyS.S.Intravenous levetiracetam vs phenytoin for status epilepticus and cluster seizures: A prospective, randomized study. , 2017, 2017, 8–12. doi: 10.1016/j.seizure.2017.05.001Open DOISearch in Google Scholar
Handral A., Veerappa B.G., Gowda S.K., Benakappa N., Benakappa A. Levetiracetam versus Fosphenytoin in pediatric convulsive status epilepticus: a randomized controlled trail. Journal of Pediatric Neurosciences, 2020, 2020, 252–256. doi: 10.4103/jpn.JPN_109_19HandralA.VeerappaB.G.GowdaS.K.BenakappaN.BenakappaA.Levetiracetam versus Fosphenytoin in pediatric convulsive status epilepticus: a randomized controlled trail. , 2020, 2020, 252–256. doi: 10.4103/jpn.JPN_109_19Open DOISearch in Google Scholar
Kapur J., Elm J., Chamberlain J.M., Barsan W., Cloyd J., Lowenstein D. et al. Randomized trial of three anticonvulsant medications for status epilepticus. New England Journal of Medicine, 2019, 2019, 2103–2113. doi: 10.1056/NEJMoal1905795KapurJ.ElmJ.ChamberlainJ.M.BarsanW.CloydJ.LowensteinD.Randomized trial of three anticonvulsant medications for status epilepticus. , 2019, 2019, 2103–2113. doi: 10.1056/NEJMoal1905795Open DOISearch in Google Scholar
Lyttle M.D., Rainford N.E.A., Gamble C., Messahel S., Humphreys A., Hickey H. et al. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet, 2019, 2019 (10186), 2125–2134. doi: 10.1016/S01406736(19)30724-xLyttleM.D.RainfordN.E.A.GambleC.MessahelS.HumphreysA.HickeyH.Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. , 2019, 2019 (10186), 2125–2134. doi: 10.1016/S01406736(19)30724-xOpen DOISearch in Google Scholar
Misra U.K., Kalita J., Maurya P.K. Levetiracetam versus lorazepam in status epilepticus: a randomized, open labelled pilot study. Journal of Neurology, 2012, 2012, 645–648. doi: 10.1007/s00415-011-6227-2MisraU.K.KalitaJ.MauryaP.K.Levetiracetam versus lorazepam in status epilepticus: a randomized, open labelled pilot study. , 2012, 2012, 645–648. doi: 10.1007/s00415-011-6227-221898137Open DOISearch in Google Scholar
Mundlamuri R.C., Sinha S., Subbakrishna D.K., Prathyusha P.V., Nagappa M., Bindu P.S. et al. Management of generalised convulsive status epilepticus (SE): A prospective randomized controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam – Pilot study. Epilepsy Research, 2015, 2015, 52–58. doi: 10.1016/j.eplepsyres.2015.04.013MundlamuriR.C.SinhaS.SubbakrishnaD.K.PrathyushaP.V.NagappaM.BinduP.S.Management of generalised convulsive status epilepticus (SE): A prospective randomized controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam – Pilot study. , 2015, 2015, 52–58. doi: 10.1016/j.eplepsyres.2015.04.01326088885Open DOISearch in Google Scholar
Nalisetty S., Kandasamy S., Sridharan B., Vijayakumar V., Sangaralingam T., Krishnamoorthi N. Clinical effectiveness of Levetiracetam compared to Fosphenytoin in the treatment of benzodiazepine refractory convulsive status epilepticus. The Indian Journal of Pediatrics, 2020, 2020, 512–519. doi: 10.1007/s12098-020-03221-2NalisettyS.KandasamyS.SridharanB.VijayakumarV.SangaralingamT.KrishnamoorthiN.Clinical effectiveness of Levetiracetam compared to Fosphenytoin in the treatment of benzodiazepine refractory convulsive status epilepticus. , 2020, 2020, 512–519. doi: 10.1007/s12098-020-03221-2Open DOISearch in Google Scholar
Navarro V., Dagron C., Elie C., Lamhaut L., Demeret S., Urien S. Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonacepam in status epilepticus (SAMUKeppra): a randomized, double-blind, phase 3 trial. Lancet Neurology, 2016, 2016, 47–55. doi: 10.1016/S1474-442(15)00296-3NavarroV.DagronC.ElieC.LamhautL.DemeretS.UrienS.Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonacepam in status epilepticus (SAMUKeppra): a randomized, double-blind, phase 3 trial. , 2016, 2016, 47–55. doi: 10.1016/S1474-442(15)00296-3Open DOISearch in Google Scholar
Nazir M., Rayees A.T., Asimi R., Syed W.A. Comparative efficacy of IV phenytoin, IV valproate, and IV levetiracetam in childhood status epilepticus. Journal of Epilepsy Research, 2020, 2020, 69–73. doi: 10.14581/jer.20011NazirM.RayeesA.T.AsimiR.SyedW.A.Comparative efficacy of IV phenytoin, IV valproate, and IV levetiracetam in childhood status epilepticus. , 2020, 2020, 69–73. doi: 10.14581/jer.20011790304433659198Open DOISearch in Google Scholar
Nene D., Mundlamuri R.C., Satishchandra P., Prathyusha P.V., Nagappa M., Bindu P.S. et al. Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with genralized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study. Seizure: European Journal of Epileptology, 2019, 2019, 111–117. doi: 10.1016/j.seizure.2019.01.015NeneD.MundlamuriR.C.SatishchandraP.PrathyushaP.V.NagappaM.BinduP.S.Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with genralized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study. , 2019, 2019, 111–117. doi: 10.1016/j.seizure.2019.01.01530682680Open DOISearch in Google Scholar
Nicolas J.-M., Hannestad J., Holden D., Kervyn S., Nabulsi N., Tytgat D. et al. Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action. Epilepsia, 2016, 2016, 201–209. doi: 10.1111/epi.13267NicolasJ.-M.HannestadJ.HoldenD.KervynS.NabulsiN.TytgatD.Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action. , 2016, 2016, 201–209. doi: 10.1111/epi.1326726663401Open DOISearch in Google Scholar
Noureen N., Khan S., Khursheed A., Iqbal I., Maryam M., Sharib S.M. et al. Clinical efficacy and safety of injectable levetiracetam versus phenytoin as second-line therapy in the management of generalized convulsive status epilepticus in children: an open-label randomized controlled trial. Journal of Clinical Neurology, 2019, 2019, 468–472. doi: 10.3988/jcn.2019.15.4.468NoureenN.KhanS.KhursheedA.IqbalI.MaryamM.SharibS.M.Clinical efficacy and safety of injectable levetiracetam versus phenytoin as second-line therapy in the management of generalized convulsive status epilepticus in children: an open-label randomized controlled trial. , 2019, 2019, 468–472. doi: 10.3988/jcn.2019.15.4.468678546531591834Open DOISearch in Google Scholar
Redecker J., Wittstock M., Rösche J. The efficacy of different kinds of intravenously applied antiepileptic drugs in the treatment of status epilepticus. How can it be determined? Epilepsy & Behavior, 2017, 71, 35–38. doi: 10.1016/j.yebeh.2017.03.18RedeckerJ.WittstockM.RöscheJ.The efficacy of different kinds of intravenously applied antiepileptic drugs in the treatment of status epilepticus. How can it be determined?, 2017, 71, 35–38. doi: 10.1016/j.yebeh.2017.03.18Open DOISearch in Google Scholar
Rösche J., Dudek M., Teleki A., Godau J., Bösel J. Levetiracetam in der Behandlung des Status Epilepticus – ein update. Fortschritte der Neurologie – Psychiatrie, 2019, 2019, 357–363. doi: 10.1055/a-0832-8652RöscheJ.DudekM.TelekiA.GodauJ.BöselJ.Levetiracetam in der Behandlung des Status Epilepticus – ein update. , 2019, 2019, 357–363. doi: 10.1055/a-0832-865231261415Open DOISearch in Google Scholar
Rösche J., Pohley I., Rantsch K., Walter U., Benecke R. Erfahrungen mit Levetiracetam in der Behandlung des Status epilepticus. Fortschritte der Neurologie – Psychiatrie, 2013, 2013, 21–27. doi: 10.1055/s-0032-1312951RöscheJ.PohleyI.RantschK.WalterU.BeneckeR.Erfahrungen mit Levetiracetam in der Behandlung des Status epilepticus. , 2013, 2013, 21–27. doi: 10.1055/s-0032-131295122890440Open DOISearch in Google Scholar
Rosenow F., Weber J.R. Dohmen C., Hamer H.M., Holtkamp M., Jahnke K. et al. Status epilepticus im Erwachsenenalter, S2k-Leitlinie, 2020. In: Deutsche Gesellschaft für Neurologie (ed.), Leitlinien für Diagnostik und Therapie in der Neurologie. On-line: www.dgn.org/leitlinien (last visit May 2nd 2021).RosenowF.WeberJ.R.DohmenC.HamerH.M.HoltkampM.JahnkeK.Status epilepticus im Erwachsenenalter, S2k-Leitlinie, 2020. In: . On-line: www.dgn.org/leitlinien (last visit May 2nd 2021).10.1007/s00115-020-01036-2848425733751150Search in Google Scholar
Sathe A.G., Elm J.J., Cloyd J.C., Chamberlain J.M., Silbergleit R., Kapur J. et al. The association of patients weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus. Epilepsia, 2020, 2020, e66–e70. doi: 10.111/epi.16534SatheA.G.ElmJ.J.CloydJ.C.ChamberlainJ.M.SilbergleitR.KapurJ.The association of patients weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus. , 2020, 2020, e66–e70. doi: 10.111/epi.16534Open DOISearch in Google Scholar
Vignesh V., Rameshkumar R., Mahadevan S. Comparison of Phenytoin, Valproate and Levetiracetam in Pediatric convulsive status epilepticus: A randomized double-blind controlled clinical trial. Indian Pediatrics, 2020, 2020, 222–227.VigneshV.RameshkumarR.MahadevanS.Comparison of Phenytoin, Valproate and Levetiracetam in Pediatric convulsive status epilepticus: A randomized double-blind controlled clinical trial. , 2020, 2020, 222–227.10.1007/s13312-020-1755-4Search in Google Scholar
Wani G., Imram A., Dhawan N., Gupta A., Giri J.I. Levetiracetam versus phenytoin in children with status epilepticus. Journal of Family Medicine and Primary Care, 2019, 2019, 3367–3371. doi: 10.4103/jfmpc.jfmpc_750_19WaniG.ImramA.DhawanN.GuptaA.GiriJ.I.Levetiracetam versus phenytoin in children with status epilepticus. , 2019, 2019, 3367–3371. doi: 10.4103/jfmpc.jfmpc_750_19685742631742170Open DOISearch in Google Scholar
Wongjirattikarn R., Sawanyawisuth K., Pranboon S., Tiamkao S., Tiamkao S. Can generic intravenous levetiracetam be used for acute repetitive convulsive seizure or status epilepticus? A randimized controlled trial. Neurology and Therapy, 2019, 2019, 425–431. doi: 10.1007/s40120-019-00150-xWongjirattikarnR.SawanyawisuthK.PranboonS.TiamkaoS.TiamkaoS.Can generic intravenous levetiracetam be used for acute repetitive convulsive seizure or status epilepticus? A randimized controlled trial. , 2019, 2019, 425–431. doi: 10.1007/s40120-019-00150-x685891831407191Open DOISearch in Google Scholar
Yasiry Z., Shorvon S.D. The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: A meta-analysis of published studies. Seizure, 2014, 2014, 167–174. doi: 10.1016/j.seizure.2013.12.007YasiryZ.ShorvonS.D.The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: A meta-analysis of published studies. , 2014, 2014, 167–174. doi: 10.1016/j.seizure.2013.12.00724433665Open DOISearch in Google Scholar