<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2016-0010_s_001"><h3>Introduction</h3><p>Medial temporal lobe epilepsy (MTLE) is the most frequent form of epilepsy in adulthood. It is classified as local/regional epilepsy. However, there is increasing evidence of the involvement of both temporal lobes and this provides abundant arguments to question this view, and consider MTLE as one of the typical bilateral system epilepsies.</p></sec><sec id="j_joepi-2016-0010_s_002"><h3>Aim</h3><p>To provide a contemporary review of medial temporal lobe epilepsy, discussing the bilateral aspects, with reference to epilepsy surgery.</p></sec><sec id="j_joepi-2016-0010_s_003"><h3>Methods</h3><p>A literature review and a resume of the author’s own experiences with MTLE patients.</p></sec><sec id="j_joepi-2016-0010_s_004"><h3>Results</h3><p>Recent electrophysiological and neuroimaging data provide convincing data supporting that MTLE is a bilateral disease. The uni-and bilateral features form a continuum and the participation rate of the two temporal lobes determine course and surgical perspective of the individual patient.</p></sec><sec id="j_joepi-2016-0010_s_005"><h3>Conclusions</h3><p>The contradictory data of invasive presurgical evaluations of MTLE patients suggest that there need to identify further indicatory markers of bilaterality and thus change the presurgical evaluation from the non-invasive towards the invasive ways. The mechanisms of the interrelationship between the two temporal lobes in MTLE warrants further research.</p></sec></abstract>

IntroductionMedial temporal lobe epilepsy (MTLE) is the most frequent form of epilepsy in adulthood. It is classified as local/regional epilepsy. However, there is increasing evidence of the involvement of both temporal lobes and this provides abundant arguments to question this view, and consider MTLE as one of the typical bilateral system epilepsies.AimTo provide a contemporary review of medial temporal lobe epilepsy, discussing the bilateral aspects, with reference to epilepsy surgery.MethodsA literature review and a resume of the author’s own experiences with MTLE patients.ResultsRecent electrophysiological and neuroimaging data provide convincing data supporting that MTLE is a bilateral disease. The uni-and bilateral features form a continuum and the participation rate of the two temporal lobes determine course and surgical perspective of the individual patient.ConclusionsThe contradictory data of invasive presurgical evaluations of MTLE patients suggest that there need to identify further indicatory markers of bilaterality and thus change the presurgical evaluation from the non-invasive towards the invasive ways. The mechanisms of the interrelationship between the two temporal lobes in MTLE warrants further research.

The medial temporal lobe epilepsy is a bilateral disease – novel aspects

Journal of Epileptology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The medial temporal lobe epilepsy is a bilateral disease \u2013 novel aspects"}

IntroductionMedial temporal lobe epilepsy (MTLE) is the most frequent form of epilepsy in adulthood. It is classified as local/regional epilepsy. However,...

The medial temporal lobe epilepsy is a bilateral disease – novel aspects

Published Online: Nov 22, 2016

Page range: 141 - 155

Received: Oct 03, 2016

Accepted: Nov 08, 2016

DOI: https://doi.org/10.21307/joepi-2016-0010

Keywords
medial temporal lobe epilepsy (MTLE), bilateral network, secondary epilepsy, bilaterality and surgical outcome

© 2016 Péter Halász et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The medial temporal lobe epilepsy is a bilateral disease – novel aspects

Published Online: Nov 22, 2016

Page range: 141 - 155

Received: Oct 03, 2016

Accepted: Nov 08, 2016

DOI: https://doi.org/10.21307/joepi-2016-0010

Keywordsmedial temporal lobe epilepsy (MTLE), bilateral network, secondary epilepsy, bilaterality and surgical outcome

© 2016 Péter Halász et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
medial temporal lobe epilepsy (MTLE), bilateral network, secondary epilepsy, bilaterality and surgical outcome