<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Autoantibodies may cause severe hemolytic anemia, but only rarely are they the cause of a hemolytic transfusion reaction due to the destruction of transfused allogeneic blood. In two patients, autoantibody was detected shortly after blood transfusion. The first case was a D-negative patient who produced an autoanti-Ce and subsequently developed hemoglobinuria and hyperbilirubinemia. The second case was a patient who developed an autoanti-Wr<sup>b</sup> that caused severe hemolysis that resulted in death. <bold><italic>Immunohematology</italic></bold> 1996;12:80–83.</p></abstract>

Autoantibodies may cause severe hemolytic anemia, but only rarely are they the cause of a hemolytic transfusion reaction due to the destruction of transfused allogeneic blood. In two patients, autoantibody was detected shortly after blood transfusion. The first case was a D-negative patient who produced an autoanti-Ce and subsequently developed hemoglobinuria and hyperbilirubinemia. The second case was a patient who developed an autoanti-Wrb that caused severe hemolysis that resulted in death. Immunohematology 1996;12:80–83.

Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion

Immunohematology

Autoantibodies may cause severe hemolytic anemia, but only rarely are they the cause of a hemolytic transfusion reaction due to the destruction of transfused...

Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion

Published Online: Nov 10, 2020

Page range: 80 - 83

DOI: https://doi.org/10.21307/immunohematology-2019-751

© 1996 D. Chan et al., published by Sciendo