<abstract xmlns="http://www.w3.org/1999/xhtml">ABO hemolytic disease of the newborn (HDN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case in which clinically significant ABO-HDN occurred in a group B neonate from anti-B of a group A2 mother. The IgG anti-B titer was much higher (256) than that found in a group A1 mother/infant control group (≤ 32). The maternal antibody screen was negative and antibodies to low-frequency antigens were not detected. Therefore, when evaluating unexplained HDN in a group B newborn of a group A mother, it may be relevant to determine the subgroup of the mother. As presented here, anti-B from a group A2 mother may, on occasion, be responsible for HDN. <bold><italic>Immunohematology</italic> 2000;16: 105–108.</bold></abstract>

ABO hemolytic disease of the newborn (HDN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B occurs more commonly in group O than in group A or B individuals. We report a case in which clinically significant ABO-HDN occurred in a group B neonate from anti-B of a group A2 mother. The IgG anti-B titer was much higher (256) than that found in a group A1 mother/infant control group (≤ 32). The maternal antibody screen was negative and antibodies to low-frequency antigens were not detected. Therefore, when evaluating unexplained HDN in a group B newborn of a group A mother, it may be relevant to determine the subgroup of the mother. As presented here, anti-B from a group A2 mother may, on occasion, be responsible for HDN. Immunohematology 2000;16: 105–108.

Significant ABO hemolytic disease of the newborn in a group B infant with a group A2 mother

Immunohematology

Significant ABO hemolytic disease of the newborn in a group B infant with a group A mother

ABO hemolytic disease of the newborn (HDN) occurs almost exclusively in infants of blood group A or B who are born to group O mothers because IgG anti-A or -B...

Significant ABO hemolytic disease of the newborn in a group B infant with a group A₂ mother

Published Online: Oct 18, 2020

Page range: 105 - 108

DOI: https://doi.org/10.21307/immunohematology-2019-587

© 2000 H. Jeon et al., published by Sciendo