<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Red blood cell (RBC) antigens represent inherited traits and as such, their expression should be constant throughout the life of an individual. We describe a patient in whom the expression of the Rh D and C antigens was lost due to the development of chronic myelogenous leukemia (CML). For this patient, this represented more than a blood bank curiosity but was of critical importance in determining further treatment of the leukemia.</p><p>The mechanisms behind changes in RBC antigens due to malignancy are reviewed for a number of antigens, antigen systems, and antigen collections. Previous case reports of RBC antigen changes due to malignancy are summarized.</p></abstract>

Red blood cell (RBC) antigens represent inherited traits and as such, their expression should be constant throughout the life of an individual. We describe a patient in whom the expression of the Rh D and C antigens was lost due to the development of chronic myelogenous leukemia (CML). For this patient, this represented more than a blood bank curiosity but was of critical importance in determining further treatment of the leukemia.The mechanisms behind changes in RBC antigens due to malignancy are reviewed for a number of antigens, antigen systems, and antigen collections. Previous case reports of RBC antigen changes due to malignancy are summarized.

Red blood cell antigen changes in malignancy: case report and review

Immunohematology

{"article-title":"Red blood cell antigen changes in malignancy: case report and review"}

Red blood cell (RBC) antigens represent inherited traits and as such, their expression should be constant throughout the life of an individual. We describe a...

Red blood cell antigen changes in malignancy: case report and review

Published Online: Oct 14, 2020

Page range: 1 - 9

DOI: https://doi.org/10.21307/immunohematology-2019-533

Keywords
leukemia, erythrocytes, antigens, mutation, ABO blood group system, Rh blood group system, MNS blood group system, Lewis blood group system, I blood group collection, chromosome abnormalities

© 2019 J.L. Winters et al., published by Sciendo

Red blood cell antigen changes in malignancy: case report and review

Published Online: Oct 14, 2020

Page range: 1 - 9

DOI: https://doi.org/10.21307/immunohematology-2019-533

Keywordsleukemia, erythrocytes, antigens, mutation, ABO blood group system, Rh blood group system, MNS blood group system, Lewis blood group system, I blood group collection, chromosome abnormalities

© 2019 J.L. Winters et al., published by Sciendo

Keywords
leukemia, erythrocytes, antigens, mutation, ABO blood group system, Rh blood group system, MNS blood group system, Lewis blood group system, I blood group collection, chromosome abnormalities