<abstract xmlns="http://www.w3.org/1999/xhtml">Many African Americans with sickle cell disease (SCD) develop alloantibodies to antigens in the Rh blood group system.Others have shown that from D– individuals, those lacking the high-incidence hrBantigen (> 98% prevalence) may be found among r’r African Americans. We describe an algorithm to locate units for African Americans with SCD and anti-hrB and -D. From 46,539 donations, 5136 listed African American as race. Our primary reference laboratory performed Rh phenotyping (D, C, c, E, e) for first-time donors and those not tested previously. Specimens typing r’r were sent to a secondary reference laboratory for hrBphenotyping after each donation.Hemoglobin S screening was performed.Of 24 donors (27 donations) who phenotyped r’r, seven donors,29.2 percent (nine donations) were hrB–.Two of seven who donated twice consistently tested hrB–. One of 24 donors initially tested hrB–, but hrB+ on repeat donation. The donor tested hrB– by a second reference laboratory. Reagents for phenotyping high-incidence antigens are often not readily available, requiring a specialized reference laboratory that adds cost and turnaround time. Our algorithm selected r’r African American donors most likely to lack hrB for further evaluation by a second reference laboratory.We felt this was the most judicious use of resources and provided the greatest opportunity to find compatible components for individuals with SCD and anti-hrB and -D. <bold><italic>Immunohematology</italic> 2002;18:82–84.</bold></abstract>

Many African Americans with sickle cell disease (SCD) develop alloantibodies to antigens in the Rh blood group system.Others have shown that from D– individuals, those lacking the high-incidence hrBantigen (> 98% prevalence) may be found among r’r African Americans. We describe an algorithm to locate units for African Americans with SCD and anti-hrB and -D. From 46,539 donations, 5136 listed African American as race. Our primary reference laboratory performed Rh phenotyping (D, C, c, E, e) for first-time donors and those not tested previously. Specimens typing r’r were sent to a secondary reference laboratory for hrBphenotyping after each donation.Hemoglobin S screening was performed.Of 24 donors (27 donations) who phenotyped r’r, seven donors,29.2 percent (nine donations) were hrB–.Two of seven who donated twice consistently tested hrB–. One of 24 donors initially tested hrB–, but hrB+ on repeat donation. The donor tested hrB– by a second reference laboratory. Reagents for phenotyping high-incidence antigens are often not readily available, requiring a specialized reference laboratory that adds cost and turnaround time. Our algorithm selected r’r African American donors most likely to lack hrB for further evaluation by a second reference laboratory.We felt this was the most judicious use of resources and provided the greatest opportunity to find compatible components for individuals with SCD and anti-hrB and -D. Immunohematology 2002;18:82–84.

An algorithm to locate hrB– donors for individuals with sickle cell disease

Association of Independent Blood Centers, Inc.

Immunohematology

An algorithm to locate hr– donors for individuals with sickle cell disease

Many African Americans with sickle cell disease (SCD) develop alloantibodies to antigens in the Rh blood group system.Others have shown that from D–...

An algorithm to locate hr^B– donors for individuals with sickle cell disease

Published Online: Oct 14, 2020

Page range: 82 - 84

DOI: https://doi.org/10.21307/immunohematology-2019-515

Keywords
algorithm, hr– donors, sickle cell disease, transfusion

© 2002 R.R. Gammon et al., published by Sciendo