<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immune-mediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient’s DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.</p></abstract>

Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immune-mediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient’s DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.

Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery

Immunohematology

Second- and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immune-mediated hemolytic anemia. We...

Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery

Published Online: May 02, 2020

Page range: 63 - 66

DOI: https://doi.org/10.21307/immunohematology-2019-423

Keywords
cefotetan, cesarean delivery, DAT, drug-induced hemolytic anemia, immune hemolytic anemia

© 2004 S. Shariatmadar et al., published by Sciendo

Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery

Published Online: May 02, 2020

Page range: 63 - 66

DOI: https://doi.org/10.21307/immunohematology-2019-423

Keywordscefotetan, cesarean delivery, DAT, drug-induced hemolytic anemia, immune hemolytic anemia

© 2004 S. Shariatmadar et al., published by Sciendo

Keywords
cefotetan, cesarean delivery, DAT, drug-induced hemolytic anemia, immune hemolytic anemia