<abstract xmlns="http://www.w3.org/1999/xhtml">FFP has occasionally been reported to generate an immune response to RBC antigens (e.g., anti-D and anti-Fya). The Council of Europe requires that each unit of FFP have less than 6 × 109/L RBCs. However, there is considerable variation internationally in the method of production and the level and assessment of RBC contamination of FFP. This study reports the case of a 63-year-old group B, D– man who received multiple transfusions of D– blood products over a 4-month period. Seven months later the patient’s antibody screen remained negative and he was transfused with seven units of D– RBCs and six units of FFP, four of which were D+. Two months later anti-D, -E, and -K were detected in his plasma. Although the anti-E and anti-K could have resulted from transfusion of antigen-positive RBCs, the anti-D could have resulted only from transfusion of the D+ FFP. The D status of FFP is currently not considered when selecting products for transfusion even though the D antigen is highly immunogenic and the level of RBC contamination of FFP is not always known. This case highlights that transfusion of FFP is a stimulus for RBC antibodies and that when a patient has had a recent transfusion of FFP, consideration should be given to obtaining a sample for pretransfusion testing within 3 days before a scheduled RBC transfusion. In addition, the D status of FFP should be considered before administering FFP to premenopausal D– women. <italic><bold>Immunohematology</bold></italic><bold>2005;21:149–51.</bold></abstract>

FFP has occasionally been reported to generate an immune response to RBC antigens (e.g., anti-D and anti-Fya). The Council of Europe requires that each unit of FFP have less than 6 × 109/L RBCs. However, there is considerable variation internationally in the method of production and the level and assessment of RBC contamination of FFP. This study reports the case of a 63-year-old group B, D– man who received multiple transfusions of D– blood products over a 4-month period. Seven months later the patient’s antibody screen remained negative and he was transfused with seven units of D– RBCs and six units of FFP, four of which were D+. Two months later anti-D, -E, and -K were detected in his plasma. Although the anti-E and anti-K could have resulted from transfusion of antigen-positive RBCs, the anti-D could have resulted only from transfusion of the D+ FFP. The D status of FFP is currently not considered when selecting products for transfusion even though the D antigen is highly immunogenic and the level of RBC contamination of FFP is not always known. This case highlights that transfusion of FFP is a stimulus for RBC antibodies and that when a patient has had a recent transfusion of FFP, consideration should be given to obtaining a sample for pretransfusion testing within 3 days before a scheduled RBC transfusion. In addition, the D status of FFP should be considered before administering FFP to premenopausal D– women. Immunohematology2005;21:149–51.

Case report: immune anti-D stimulated by transfusion of fresh frozen plasma

Immunohematology

{"article-title":"Case report: immune anti-D stimulated by transfusion of fresh frozen plasma"}

FFP has occasionally been reported to generate an immune response to RBC antigens (e.g., anti-D and anti-Fya). The Council of Europe requires that each unit of...

Case report: immune anti-D stimulated by transfusion of fresh frozen plasma

Published Online: May 01, 2020

Page range: 149 - 151

DOI: https://doi.org/10.21307/immunohematology-2019-410

Keywords
red blood cell, antibody, anti-D, contamination, fresh frozen plasma, FFP

© 2005 M. Connolly, et al., published by Sciendo

Case report: immune anti-D stimulated by transfusion of fresh frozen plasma

Published Online: May 01, 2020

Page range: 149 - 151

DOI: https://doi.org/10.21307/immunohematology-2019-410

Keywordsred blood cell, antibody, anti-D, contamination, fresh frozen plasma, FFP

© 2005 M. Connolly, et al., published by Sciendo

Keywords
red blood cell, antibody, anti-D, contamination, fresh frozen plasma, FFP