<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hb 7g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with an LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease. <italic><bold>Immunohematology</bold></italic><bold>2005;21:48–52.</bold></p></abstract>

A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hb 7g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with an LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease. Immunohematology2005;21:48–52.

Acute hemolytic transfusion reaction secondary to anti-Fy3

Immunohematology

{"article-title":"Acute hemolytic transfusion reaction secondary to anti-Fy3"}

A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African...

Acute hemolytic transfusion reaction secondary to anti-Fy3

Published Online: Apr 21, 2020

Page range: 48 - 52

DOI: https://doi.org/10.21307/immunohematology-2019-392

Keywords
Duffy blood group system, intravascular hemolysis, transfusion reaction

© 2005 H. Olteanu, et al., published by Sciendo

Acute hemolytic transfusion reaction secondary to anti-Fy3

Published Online: Apr 21, 2020

Page range: 48 - 52

DOI: https://doi.org/10.21307/immunohematology-2019-392

KeywordsDuffy blood group system, intravascular hemolysis, transfusion reaction

© 2005 H. Olteanu, et al., published by Sciendo

Keywords
Duffy blood group system, intravascular hemolysis, transfusion reaction