<abstract xmlns="http://www.w3.org/1999/xhtml">It is well known that certain combinations of alloantibodies are frequently found together. Patients with sickle cell disease (SCD) are mostly of African ancestry, and they may make anti-hrB. A transfusion of hrB–blood is often achieved by using e–(R2R2) RBCs; it is generally believed that hrB–patients readily make anti-E or a“broad-spectrum” anti-Rh34 (-HrB). We describe two multiply transfused D+ patients with SCD and a history of anti-hrB who subsequently produced anti-D. This raises the question whether anti-hrB together with anti-D is a more common antibody combination than anti-hrB with anti-E or anti-Rh34. <italic><bold>Immunohematology</bold></italic><bold>2007;23:158–60.</bold></abstract>

It is well known that certain combinations of alloantibodies are frequently found together. Patients with sickle cell disease (SCD) are mostly of African ancestry, and they may make anti-hrB. A transfusion of hrB–blood is often achieved by using e–(R2R2) RBCs; it is generally believed that hrB–patients readily make anti-E or a“broad-spectrum” anti-Rh34 (-HrB). We describe two multiply transfused D+ patients with SCD and a history of anti-hrB who subsequently produced anti-D. This raises the question whether anti-hrB together with anti-D is a more common antibody combination than anti-hrB with anti-E or anti-Rh34. Immunohematology2007;23:158–60.

A confusion in antibody identification: anti-D production after anti-hrB

Immunohematology

A confusion in antibody identification: anti-D production after anti-hr

It is well known that certain combinations of alloantibodies are frequently found together. Patients with sickle cell disease (SCD) are mostly of African...

A confusion in antibody identification: anti-D production after anti-hr^B

Published Online: Apr 01, 2020

Page range: 158 - 160

DOI: https://doi.org/10.21307/immunohematology-2019-334

© 2007 C. Lomas-Francis, et al., published by Sciendo