<abstract xmlns="http://www.w3.org/1999/xhtml">Anti-IT is an unusual specificity originally described as a naturally occurring cold agglutinin. The antibody reacts strongly with cord RBCs, weakly with adult I RBCs, and most weakly with the rare adult i RBCs. IgG anti-IT in patients with hemolytic anemia has been associated with Hodgkin’s lymphoma. Difficulties in blood grouping tests and the presence of a warm reactive agglutinin in samples from two patients with hemolytic anemia led to further serologic studies and the identification of anti-IT. In both cases, the anti-IT was a rarely encountered IgM warm reactive agglutinin; in one case, the IgG component was also anti-IT, whereas in the second case the IgG antibody was broadly reactive. The unusual serologic finding of anti-IT prompted further clinical evaluation for lymphoproliferative disease in these two patients. <italic><bold>Immunohematology</bold></italic><bold>2009;25:60–62.</bold></abstract>

Anti-IT is an unusual specificity originally described as a naturally occurring cold agglutinin. The antibody reacts strongly with cord RBCs, weakly with adult I RBCs, and most weakly with the rare adult i RBCs. IgG anti-IT in patients with hemolytic anemia has been associated with Hodgkin’s lymphoma. Difficulties in blood grouping tests and the presence of a warm reactive agglutinin in samples from two patients with hemolytic anemia led to further serologic studies and the identification of anti-IT. In both cases, the anti-IT was a rarely encountered IgM warm reactive agglutinin; in one case, the IgG component was also anti-IT, whereas in the second case the IgG antibody was broadly reactive. The unusual serologic finding of anti-IT prompted further clinical evaluation for lymphoproliferative disease in these two patients. Immunohematology2009;25:60–62.

Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-IT in two cases

Immunohematology

Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-I in two cases

Anti-IT is an unusual specificity originally described as a naturally occurring cold agglutinin. The antibody reacts strongly with cord RBCs, weakly with adult...

Clinical evaluation for lymphoproliferative disease prompted by finding of IgM warm autoanti-I^T in two cases

Article Category: Case Report

Published Online: Mar 17, 2020

Page range: 60 - 62

DOI: https://doi.org/10.21307/immunohematology-2019-232

© 2009 R.M. Leger, et al., published by Sciendo