<abstract xmlns="http://www.w3.org/1999/xhtml">Antigens in the Gerbich blood group system are expressed on glycophorin C (GPC) and glycophorin D (GPD), which are both encoded by a single gene, <italic>GYPC</italic>. The <italic>GYPC</italic> gene is located on the long arm of chromosome 2, and Gerbich antigens are inherited as autosomal dominant traits. There are 11 antigens in the Gerbich blood group system, six of high prevalence (Ge2, Ge3, Ge4, GEPL [Ge10<xref ref-type="fn" rid="j_immunohematology-2019-204_fn_001">*</xref>], GEAT [Ge11<xref ref-type="fn" rid="j_immunohematology-2019-204_fn_001">*</xref>], GETI [Ge12<xref ref-type="fn" rid="j_immunohematology-2019-204_fn_001">*</xref>]) and five of low prevalence (Wb [Ge5], Lsa [Ge6], Ana [Ge7], Dha [Ge8], GEIS [Ge9]). GPC and GPD interact with protein 4.1R, contributing stability to the RBC membrane. Reduced levels of GPC and GPD are associated with hereditary elliptocytosis, and Gerbich antigens act as receptors for the malarial parasite <italic>Plasmodium falciparum</italic>. Anti-Ge2 and anti-Ge3 have caused hemolytic transfusion reactions, and anti-Ge3 has produced hemolytic disease of the fetus and newborn (HDFN). <italic><bold>Immunohematology</bold></italic><bold>2010;26:60–65.</bold></abstract>

Antigens in the Gerbich blood group system are expressed on glycophorin C (GPC) and glycophorin D (GPD), which are both encoded by a single gene, GYPC. The GYPC gene is located on the long arm of chromosome 2, and Gerbich antigens are inherited as autosomal dominant traits. There are 11 antigens in the Gerbich blood group system, six of high prevalence (Ge2, Ge3, Ge4, GEPL [Ge10*], GEAT [Ge11*], GETI [Ge12*]) and five of low prevalence (Wb [Ge5], Lsa [Ge6], Ana [Ge7], Dha [Ge8], GEIS [Ge9]). GPC and GPD interact with protein 4.1R, contributing stability to the RBC membrane. Reduced levels of GPC and GPD are associated with hereditary elliptocytosis, and Gerbich antigens act as receptors for the malarial parasite Plasmodium falciparum. Anti-Ge2 and anti-Ge3 have caused hemolytic transfusion reactions, and anti-Ge3 has produced hemolytic disease of the fetus and newborn (HDFN). Immunohematology2010;26:60–65.

The Gerbich blood group system: a review

Immunohematology

{"article-title":"The Gerbich blood group system: a review"}

Antigens in the Gerbich blood group system are expressed on glycophorin C (GPC) and glycophorin D (GPD), which are both encoded by a single gene, GYPC. The...

The Gerbich blood group system: a review

Article Category: Review

Published Online: Mar 12, 2020

Page range: 60 - 64

DOI: https://doi.org/10.21307/immunohematology-2019-204

© 2010 P.S. Walker, et al., published by Sciendo