<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Antibodies of apparent D specificity may be found in D+ patients. We report a D+, multi-transfused Caucasian woman with myelodysplasia who exhibited several alloantibodies. One antibody was a moderately strong (2+) anti-D that persisted for 9 months, until the woman died. Molecular analysis of the patient’s RHD gene identified the rare weak D type 21 (938C>T) allele. D alloantibodies do not occur in patients with most weak D types, but some patients with a weak D phenotype, including those with type 21, can produce antibodies to nonself epitopes of the wild-type D antigen. <italic><bold>Immunohematology</bold></italic><bold>2010;26:27–29.</bold></p></abstract>

Antibodies of apparent D specificity may be found in D+ patients. We report a D+, multi-transfused Caucasian woman with myelodysplasia who exhibited several alloantibodies. One antibody was a moderately strong (2+) anti-D that persisted for 9 months, until the woman died. Molecular analysis of the patient’s RHD gene identified the rare weak D type 21 (938C>T) allele. D alloantibodies do not occur in patients with most weak D types, but some patients with a weak D phenotype, including those with type 21, can produce antibodies to nonself epitopes of the wild-type D antigen. Immunohematology2010;26:27–29.

Alloimmunization to the D antigen by a patient with weak D type 21

Immunohematology

{"article-title":"Alloimmunization to the D antigen by a patient with weak D type 21"}

Antibodies of apparent D specificity may be found in D+ patients. We report a D+, multi-transfused Caucasian woman with myelodysplasia who exhibited several...

Alloimmunization to the D antigen by a patient with weak D type 21

Article Category: Case Report

Published Online: Mar 12, 2020

Page range: 27 - 29

DOI: https://doi.org/10.21307/immunohematology-2019-197

© 2010 H. McGann, et al., published by Sciendo