<abstract xmlns="http://www.w3.org/1999/xhtml"><p>AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWj– phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear. <italic><bold>Immunohematology</bold></italic><bold> 2011;27:83–88.</bold></p></abstract>

AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWj– phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear. Immunohematology 2011;27:83–88.

Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review

Department of Clinical Haematology & BMT Service

Immunohematology

AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent...

Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review

Article Category: Case Report

Published Online: Mar 11, 2020

Page range: 83 - 88

DOI: https://doi.org/10.21307/immunohematology-2019-179

© 2011 G. Grigoriadis, et al., published by Sciendo