<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Both anaphylactic and anaphylactoid reactions to transfused blood products and plasma derivatives have occurred in IgA-deficient patients with antibodies to IgA. This study reports the concentration of IgA in various blood products to assist in the development of treatment protocols for IgA-deficient patients. Five types of blood products and seven types of plasma derivatives were tested for the presence of IgA using a semiquantitative hemagglutination inhibition method. The concentration of IgA was measured by radial immunodiffusion and enzyme-linked immunosorbent assay techniques. Blood products which consistently contained IgA less than 0.05 mg/dL (the present definition for IgA deficiency used by the American Red Cross Rare Donor Registry) were from IgA-deficient donors, deglycerolized red blood cells (RBCs) prepared with an extra wash cycle, and RBCs washed using a total volume of approximately 1300 mL of 0.9 percent sodium chloride.</p></abstract>

Both anaphylactic and anaphylactoid reactions to transfused blood products and plasma derivatives have occurred in IgA-deficient patients with antibodies to IgA. This study reports the concentration of IgA in various blood products to assist in the development of treatment protocols for IgA-deficient patients. Five types of blood products and seven types of plasma derivatives were tested for the presence of IgA using a semiquantitative hemagglutination inhibition method. The concentration of IgA was measured by radial immunodiffusion and enzyme-linked immunosorbent assay techniques. Blood products which consistently contained IgA less than 0.05 mg/dL (the present definition for IgA deficiency used by the American Red Cross Rare Donor Registry) were from IgA-deficient donors, deglycerolized red blood cells (RBCs) prepared with an extra wash cycle, and RBCs washed using a total volume of approximately 1300 mL of 0.9 percent sodium chloride.

Immunoglobulin A (IgA) levels in blood products and plasma derivatives

Immunohematology

{"article-title":"Immunoglobulin A (IgA) levels in blood products and plasma derivatives"}

Both anaphylactic and anaphylactoid reactions to transfused blood products and plasma derivatives have occurred in IgA-deficient patients with antibodies to...

Immunoglobulin A (IgA) levels in blood products and plasma derivatives

Published Online: Dec 29, 2020

Page range: 5 - 9

DOI: https://doi.org/10.21307/immunohematology-2019-1085

© 1988 S. M. Fox et al., published by Sciendo