<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Cromer-related blood group antigens are located on the complement regulatory glycoprotein, decay-accelerating factor (DAF). DAF is not detectable on red cells from individuals with a Cromer<sub>null</sub> phenotype (termed Inab), which is probably an inherited condition. DAF is also absent from a subpopulation of red cells (PNH) III) from patients with paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematological defect. PNH III red cells, like Inab cells, lack all the Cromer-related antigens described to date.</p></abstract>

Cromer-related blood group antigens are located on the complement regulatory glycoprotein, decay-accelerating factor (DAF). DAF is not detectable on red cells from individuals with a Cromernull phenotype (termed Inab), which is probably an inherited condition. DAF is also absent from a subpopulation of red cells (PNH) III) from patients with paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematological defect. PNH III red cells, like Inab cells, lack all the Cromer-related antigens described to date.

Cromer-related blood group antigens and the glycosyl phosphatidylinositol-linked protein, decay-accelerating factor DAF (CD55)

South Western Regional Transfusion Centre

Immunohematology

Cromer-related blood group antigens are located on the complement regulatory glycoprotein, decay-accelerating factor (DAF). DAF is not detectable on red cells...

Cromer-related blood group antigens and the glycosyl phosphatidylinositol-linked protein, decay-accelerating factor DAF (CD55)

Published Online: Dec 20, 2020

Page range: 27 - 29

DOI: https://doi.org/10.21307/immunohematology-2019-1036

© 1990 M.E. Reid et al., published by Sciendo.