<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The authors studied an example of red cell anti-JMH (John Milton Hagen) that exhibited several characteristics of a possible clinically significant antibody able to cause red cell destruction in vivo. Strong serological reactivity, a positive monocyte monolayer assay, and immunoglobulin subclass determination as IgG3 all indicate possible ability to destroy red cells. A <sup>51</sup>Cr-labeled red cell survival study was not done as the patient did not require red cell transfusions but may be recommended for this patient if transfusions become necessary.</p></abstract>

The authors studied an example of red cell anti-JMH (John Milton Hagen) that exhibited several characteristics of a possible clinically significant antibody able to cause red cell destruction in vivo. Strong serological reactivity, a positive monocyte monolayer assay, and immunoglobulin subclass determination as IgG3 all indicate possible ability to destroy red cells. A 51Cr-labeled red cell survival study was not done as the patient did not require red cell transfusions but may be recommended for this patient if transfusions become necessary.

An example of anti-JMH with characteristics of a clinically significant antibody

Immunohematology

{"article-title":"An example of anti-JMH with characteristics of a clinically significant antibody"}

The authors studied an example of red cell anti-JMH (John Milton Hagen) that exhibited several characteristics of a possible clinically significant antibody...

An example of anti-JMH with characteristics of a clinically significant antibody

Published Online: Dec 20, 2020

Page range: 9 - 11

DOI: https://doi.org/10.21307/immunohematology-2019-1031

© 1990 J. Geisland et al., published by Sciendo.