<abstract xmlns="http://www.w3.org/1999/xhtml">Anti-Dia can mediate hemolytic disease of the fetus and newborn, but it is unclear if it can cause hemolytic transfusion reactions (HTRs). To date, there has only been one report of a possible immediate HTR attributed to anti-Dia. Our case report details an immediate HTR due to anti-Dia in a patient with pre-existing liver failure. This reaction triggered multi-organ failure, and the patient subsequently died. This case also highlights the importance of considering HTRs even when routine antibody screening has been unremarkable, particularly when electronic crossmatch is used, because of the potential for an alloantibody against a low-prevalence antigen. <italic><bold>Immunohematology</bold></italic><bold>2015;31:163–165.</bold></abstract>

Anti-Dia can mediate hemolytic disease of the fetus and newborn, but it is unclear if it can cause hemolytic transfusion reactions (HTRs). To date, there has only been one report of a possible immediate HTR attributed to anti-Dia. Our case report details an immediate HTR due to anti-Dia in a patient with pre-existing liver failure. This reaction triggered multi-organ failure, and the patient subsequently died. This case also highlights the importance of considering HTRs even when routine antibody screening has been unremarkable, particularly when electronic crossmatch is used, because of the potential for an alloantibody against a low-prevalence antigen. Immunohematology2015;31:163–165.

Suspected acute hemolytic transfusion reaction mediated by anti-Dia

Immunohematology

Suspected acute hemolytic transfusion reaction mediated by anti-Di

Anti-Dia can mediate hemolytic disease of the fetus and newborn, but it is unclear if it can cause hemolytic transfusion reactions (HTRs). To date, there has...

Suspected acute hemolytic transfusion reaction mediated by anti-Di^a

Article Category: Case Report

Published Online: Oct 26, 2019

Page range: 163 - 165

DOI: https://doi.org/10.21307/immunohematology-2019-087

Keywords
Anti-Di, transfusion reaction, low prevalence, alloantibodies

© 2015 A. Bennett et al., published by Sciendo