<abstract xmlns="http://www.w3.org/1999/xhtml">Antibodies against Lutheran blood group antigens have been observed during first-time pregnancy. Samples from a woman of African descent were tested in our immunohematology laboratory on several occasions since 2001. Her samples were phenotyped as Lu(a+b−), and anti-Lub was suspected but not identified. She was asked to make autologous donations in preparation for her delivery, which she did. In 2010, two antibodies were identified: anti-Lea and -Lub. Six years later, a third investigation was requested. This time, an antibody directed at a high-prevalence Lutheran antigen was found in addition to the anti-Lea and -Lub previously observed. Her serum was compatible with three out of five Lu(a−b−) reagent red blood cells (RBCs). One of the incompatible Lu(a−b−) reagent RBCs was known to be In(Lu) (<italic>KLF1</italic> mutation). The genetic background of the other reagent RBC was unknown. The <italic>LU</italic> cDNA sequence analysis revealed the presence of the c.230G>A (Lua), c.679C>T (LU:–16), and a silent polymorphism c.1227G>T. Anti-Lu16 was highly suspected. This would be the fifth case of LU:–16 with antibodies reported, all within women of African heritage with the Lu(a+b−) phenotype. Hemolytic disease of the fetus and newborn was not noted in these cases. <italic><bold>Immunohematology</bold></italic><bold>2017;33:110–113.</bold></abstract>

Antibodies against Lutheran blood group antigens have been observed during first-time pregnancy. Samples from a woman of African descent were tested in our immunohematology laboratory on several occasions since 2001. Her samples were phenotyped as Lu(a+b−), and anti-Lub was suspected but not identified. She was asked to make autologous donations in preparation for her delivery, which she did. In 2010, two antibodies were identified: anti-Lea and -Lub. Six years later, a third investigation was requested. This time, an antibody directed at a high-prevalence Lutheran antigen was found in addition to the anti-Lea and -Lub previously observed. Her serum was compatible with three out of five Lu(a−b−) reagent red blood cells (RBCs). One of the incompatible Lu(a−b−) reagent RBCs was known to be In(Lu) (KLF1 mutation). The genetic background of the other reagent RBC was unknown. The LU cDNA sequence analysis revealed the presence of the c.230G>A (Lua), c.679C>T (LU:–16), and a silent polymorphism c.1227G>T. Anti-Lu16 was highly suspected. This would be the fifth case of LU:–16 with antibodies reported, all within women of African heritage with the Lu(a+b−) phenotype. Hemolytic disease of the fetus and newborn was not noted in these cases. Immunohematology2017;33:110–113.

A LU:−16 individual with antibodies

Immunohematology

{"article-title":"A LU:−16 individual with antibodies"}

Antibodies against Lutheran blood group antigens have been observed during first-time pregnancy. Samples from a woman of African descent were tested in our...

A LU:−16 individual with antibodies

Article Category: Case Report

Published Online: Oct 09, 2019

Page range: 110 - 113

DOI: https://doi.org/10.21307/immunohematology-2019-016

Keywords
Lutheran, high-prevalence antigen, African, pregnancy

© 2017 C. Éthier et al., published by Sciendo

A LU:−16 individual with antibodies

Article Category: Case Report

Published Online: Oct 09, 2019

Page range: 110 - 113

DOI: https://doi.org/10.21307/immunohematology-2019-016

KeywordsLutheran, high-prevalence antigen, African, pregnancy

© 2017 C. Éthier et al., published by Sciendo

Keywords
Lutheran, high-prevalence antigen, African, pregnancy