<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Cold-reactive autoagglutinins may mask the presence of underlying clinically significant alloantibodies. Adsorption with rabbit red blood cells (RBCs) or stroma can remove cold autoagglutinins found in the patient’s plasma/serum that are directed towards antigens expressed on the surface of rabbit RBCs. By removing these cold autoagglutinins, it is then possible to determine whether any underlying alloantibody reactivity is present. Although this method may also unintentionally adsorb alloantibodies directed towards antigens found on rabbit RBCs, it is still a widely used and convenient method to remove cold autoagglutinins. <italic><bold>Immunohematology</bold></italic> <bold>2018;34:46–48.</bold></p>
</abstract>

Cold-reactive autoagglutinins may mask the presence of underlying clinically significant alloantibodies. Adsorption with rabbit red blood cells (RBCs) or stroma can remove cold autoagglutinins found in the patient’s plasma/serum that are directed towards antigens expressed on the surface of rabbit RBCs. By removing these cold autoagglutinins, it is then possible to determine whether any underlying alloantibody reactivity is present. Although this method may also unintentionally adsorb alloantibodies directed towards antigens found on rabbit RBCs, it is still a widely used and convenient method to remove cold autoagglutinins. Immunohematology 2018;34:46–48.

Adsorption of cold agglutinins with rabbit red blood cells

Immunohematology

{"article-title":"Adsorption of cold agglutinins with rabbit red blood cells"}

Cold-reactive autoagglutinins may mask the presence of underlying clinically significant alloantibodies. Adsorption with rabbit red blood cells (RBCs) or...

Adsorption of cold agglutinins with rabbit red blood cells

Published Online: Oct 16, 2019

Page range: 46 - 48

DOI: https://doi.org/10.21307/immunohematology-2018-008

© 2018 A. Cobaugh, published by Sciendo