<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The masking of clinically significant alloantibodies by warm autoantibodies presents challenges in pretransfusion testing. The adoption of transfusion practices such as the issuing of “least incompatible” red blood cells (RBCs) without a complete antibody workup is potentially unsafe for patients. Several autoadsorption methods can be used to remove autoantibody reactivity. ZZAP treatment of autologous RBCs is an efficient way to prepare the cells for autoadsorption. Autoadsorbed serum or plasma can then be used to remove autoantibody reactivity and identify clinically significant alloantibodies. <italic><bold>Immunohematology</bold></italic> <bold>2018;34: 1–3.</bold></p>
</abstract>

The masking of clinically significant alloantibodies by warm autoantibodies presents challenges in pretransfusion testing. The adoption of transfusion practices such as the issuing of “least incompatible” red blood cells (RBCs) without a complete antibody workup is potentially unsafe for patients. Several autoadsorption methods can be used to remove autoantibody reactivity. ZZAP treatment of autologous RBCs is an efficient way to prepare the cells for autoadsorption. Autoadsorbed serum or plasma can then be used to remove autoantibody reactivity and identify clinically significant alloantibodies. Immunohematology 2018;34: 1–3.

Warm autoadsorption using ZZAP

Immunohematology

{"article-title":"Warm autoadsorption using ZZAP"}

The masking of clinically significant alloantibodies by warm autoantibodies presents challenges in pretransfusion testing. The adoption of transfusion...

Warm autoadsorption using ZZAP

Published Online: Oct 16, 2019

Page range: 1 - 3

DOI: https://doi.org/10.21307/immunohematology-2018-001

© 2018 F.M. Tsimba-Chitsva, et al., published by Sciendo