This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Ylikoski A, Erkinjuntti T, Raininko R, Sarna S, Sulkava R, Tilvis R. White matter hyperintensities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke 1995; 26(7):1171–7.YlikoskiAErkinjunttiTRaininkoRSarnaSSulkavaRTilvisR.White matter hyperintensities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke1995; 26(7):1171–7.10.1161/01.STR.26.7.1171Search in Google Scholar
Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HB. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet 2000; 356(9230):628–634.GardeEMortensenELKrabbeKRostrupELarssonHB.Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet2000; 356(9230):628–634.10.1016/S0140-6736(00)02604-0Search in Google Scholar
Sachdev PS, Thalamuthu A, Mather KA, Ames D, Wright MJ, Wen W, OATS Collaborative Research Team. White Matter Hyperintensities Are Under Strong Genetic Influence. Stroke 2016; 47(6):1422–1428.SachdevPSThalamuthuAMatherKAAmesDWrightMJWenWOATS Collaborative Research Team. White Matter Hyperintensities Are Under Strong Genetic Influence. Stroke2016; 47(6):1422–1428.10.1161/STROKEAHA.116.01253227165950Search in Google Scholar
Van Swieten JC, van den Hout JH, van Ketel BA, Hijdra A, Wokke JH, van Gijn J. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain 1991; 114 (Pt 2):761–74.Van SwietenJCvan den HoutJHvan KetelBAHijdraAWokkeJHvan GijnJ.Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain1991; 114 (Pt 2):761–74.10.1093/brain/114.2.7612043948Search in Google Scholar
Henry Feugeas MC, De Marco G, Peretti II, Godon-Hardy S, Fredy D, Claeys ES. Age-related cerebral white matter changes and pulse-wave encephalopathy: observations with three-dimensional MRI. Magn Reson Imaging 2005; 23(9):929–937.Henry FeugeasMCDe MarcoGPerettiIIGodon-HardySFredyDClaeysES. Age-related cerebral white matter changes and pulse-wave encephalopathy: observations with three-dimensional MRI. Magn Reson Imaging2005; 23(9):929–937.10.1016/j.mri.2005.09.00216310108Search in Google Scholar
Tullberg M, Fletcher E, DeCarli C, Mungas D, Reed BR, Harvey DJ, Weiner MW, Chui HC, Jagust WJ. White matter lesions impair frontal lobe function regardless of their location. Neurology 2004; 63(2):246 LP-253.TullbergMFletcherEDeCarliCMungasDReedBRHarveyDJWeinerMWChuiHCJagustWJ.White matter lesions impair frontal lobe function regardless of their location. Neurology2004; 63(2):246 LP-253.10.1212/01.WNL.0000130530.55104.B5Search in Google Scholar
Kennedy KM, Raz N. Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Res 2009; 1297:41–56.KennedyKMRazN.Pattern of normal age-related regional differences in white matter microstructure is modified by vascular risk. Brain Res2009; 1297:41–56.10.1016/j.brainres.2009.08.058275832519712671Search in Google Scholar
Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2010; 341:c3666.DebetteSMarkusHS.The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ2010; 341:c3666.10.1136/bmj.c3666291026120660506Search in Google Scholar
McGuire SA, Sherman P, Profenna L, Grogan P, Sladky J, Brown A, Robinson A, Rowland L, Hong E, Patel B, Tate D, Kawano ES, Fox P, Kochunov P. White matter hyperintensities on MRI in high-altitude U-2 pilots. Neurology 2013; 81(8):729–35.McGuireSAShermanPProfennaLGroganPSladkyJBrownARobinsonARowlandLHongEPatelBTateDKawanoESFoxPKochunovP.White matter hyperintensities on MRI in high-altitude U-2 pilots. Neurology2013; 81(8):729–35.10.1212/WNL.0b013e3182a1ab12377645923960192Search in Google Scholar
McGuire SA, Sherman PM, Wijtenburg SA, Rowland LM, Grogan PM, Sladky JH, Robinson AY, Kochunov P V. White matter hyperintensities and hypobaric exposure. Ann Neurol 2014; 76(5):719–26.McGuireSAShermanPMWijtenburgSARowlandLMGroganPMSladkyJHRobinsonAYKochunovP V.White matter hyperintensities and hypobaric exposure. Ann Neurol2014; 76(5):719–26.10.1002/ana.24264421940825164539Search in Google Scholar
McGuire SA, Sherman PM, Brown AC, Robinson AY, Tate DF, Fox PT, Kochunov P V. Hyperintense white matter lesions in 50 high-altitude pilots with neurologic decompression sickness. Aviat Space Environ Med 2012; 83(12):1117–22.McGuireSAShermanPMBrownACRobinsonAYTateDFFoxPTKochunovP V.Hyperintense white matter lesions in 50 high-altitude pilots with neurologic decompression sickness. Aviat Space Environ Med2012; 83(12):1117–22.10.3357/ASEM.3395.2012Search in Google Scholar
McGuire SA, Boone GRE, Sherman PM, Tate DF, Wood JD, Patel B, Eskandar G, Wijtenburg SA, Rowland LM, Clarke GD, Grogan PM, Sladky JH, Kochunov P V. White Matter Integrity in High-Altitude Pilots Exposed to Hypobaria. Aerosp Med Hum Perform 2016; 87(12):983–988.McGuireSABooneGREShermanPMTateDFWoodJDPatelBEskandarGWijtenburgSARowlandLMClarkeGDGroganPMSladkyJHKochunovP V.White Matter Integrity in High-Altitude Pilots Exposed to Hypobaria. Aerosp Med Hum Perform2016; 87(12):983–988.10.3357/AMHP.4585.2016Search in Google Scholar
McGuire SA, Tate DF, Wood J, Sladky JH, McDonald K, Sherman PM, Kawano ES, Rowland LM, Patel B, Wright SN, Hong E, Rasmussen J, Willis AM, Kochunov P V. Lower neurocognitive function in U-2 pilots: Relationship to white matter hyperintensities. Neurology 2014; 83(7):638–45.McGuireSATateDFWoodJSladkyJHMcDonaldKShermanPMKawanoESRowlandLMPatelBWrightSNHongERasmussenJWillisAMKochunovP V.Lower neurocognitive function in U-2 pilots: Relationship to white matter hyperintensities. Neurology2014; 83(7):638–45.10.1212/WNL.0000000000000694Search in Google Scholar
Kable Intelligence Limited. U-2 High-Altitude Reconnaissance Aircraft. 2018.Kable Intelligence Limited.U-2 High-Altitude Reconnaissance Aircraft. 2018.Search in Google Scholar
Webb JT, Woodrow AD, Maresh RW. Decompression Sickness and U-2 Operations: Summary of Research Findings and Recommendations Regarding Use of Exercise during Prebreathe. 2010.WebbJTWoodrowADMareshRW.Decompression Sickness and U-2 Operations: Summary of Research Findings and Recommendations Regarding Use of Exercise during Prebreathe. 2010.10.21236/ADA518839Search in Google Scholar
Harding R. Pressure changes and hypoxia in aviation. In: Medical aspects of harsh environments. Washington, DC: Office of The Surgeon General, Department of the Army; 2002:984–1012.HardingR.Pressure changes and hypoxia in aviation. In: Medical aspects of harsh environments. Washington, DC: Office of The Surgeon General, Department of the Army; 2002:984–1012.Search in Google Scholar
Lockheed Martin Corporation. Kelly Johnson’s Skunk Works® Legacy Lives on with U-2 Project CARE. 2015.Lockheed Martin Corporation. Kelly Johnson’s Skunk Works® Legacy Lives on with U-2 Project CARE. 2015.Search in Google Scholar
United States Air Force. U-2 modifications reduce decompression sickness. 2013.United States Air Force. U-2 modifications reduce decompression sickness. 2013.Search in Google Scholar
Conkin J, Norcross JR, Abercromby AFJ. Evidence Report: Risk of Decompression Sickness (DCS). 2016.ConkinJNorcrossJRAbercrombyAFJ.Evidence Report: Risk of Decompression Sickness (DCS). 2016.Search in Google Scholar
Garcia M. Space Station Spacewalks. Natl Aeronaut Sp Adm 2018.GarciaM.Space Station Spacewalks. Natl Aeronaut Sp Adm2018.Search in Google Scholar
Conkin J, Klein JS, Acock KE. Description of 103 Cases of Hypobaric Sickness from NASA-sponsored Research (1982-1999). NASA Technical Publication 2003-212052; 2003.ConkinJKleinJSAcockKE.Description of 103 Cases of Hypobaric Sickness from NASA-sponsored Research (1982-1999). NASA Technical Publication 2003-212052; 2003.Search in Google Scholar
Norcross J, Sherman P, McGuire S, Kochunov P. Initial Incidence of White Matter Hyperintensities on MRI in Astronauts. In: NASA Conference Paper 2015-0020963; 2016.NorcrossJShermanPMcGuireSKochunovP.Initial Incidence of White Matter Hyperintensities on MRI in Astronauts. In: NASA Conference Paper 2015-0020963; 2016.Search in Google Scholar
Alperin N, Bagci AM, Lee SH. Spaceflight-induced changes in white matter hyperintensity burden in astronauts. Neurology 2017; 89(21):2187–2191.AlperinNBagciAMLeeSH.Spaceflight-induced changes in white matter hyperintensity burden in astronauts. Neurology2017; 89(21):2187–2191.10.1212/WNL.0000000000004475Search in Google Scholar
Norcross J, Norsk P, Law J, Arias D, Conkin J, Perchonok M, Menon A, Huff J, Fogarty J, Wessel J, Whitmire S. Effects of the 8 psia / 32% O2 Atmosphere on the Human in the Spaceflight Environment. 2013.NorcrossJNorskPLawJAriasDConkinJPerchonokMMenonAHuffJFogartyJWesselJWhitmireS.Effects of the 8 psia / 32% O2 Atmosphere on the Human in the Spaceflight Environment. 2013.Search in Google Scholar
Abercromby AFJ, Conkin J, Gernhardt ML. Modeling a 15-min extravehicular activity prebreathe protocol using NASA’s exploration atmosphere (56.5 kPa/34% O2). Acta Astronaut 2015; 109:76–87.AbercrombyAFJConkinJGernhardtML.Modeling a 15-min extravehicular activity prebreathe protocol using NASA’s exploration atmosphere (56.5 kPa/34% O2). Acta Astronaut2015; 109:76–87.10.1016/j.actaastro.2014.11.039Search in Google Scholar
Pilmanis AA, Webb JT, Kannan N, Balldin U. The effect of repeated altitude exposures on the incidence of decompression sickness. Aviat Space Environ Med 2002; 73(6):525–31.PilmanisAAWebbJTKannanNBalldinU.The effect of repeated altitude exposures on the incidence of decompression sickness. Aviat Space Environ Med2002; 73(6):525–31.Search in Google Scholar
Trafton A. One giant leap for space fashion: MIT team designs sleek, skintight spacesuit. MIT News Off 2007.TraftonA.One giant leap for space fashion: MIT team designs sleek, skintight spacesuit. MIT News Off2007.Search in Google Scholar
Kumar VK, Billica RD, Waligora JM. Utility of Doppler-detectable microbubbles in the diagnosis and treatment of decompression sickness. Aviat Space Environ Med 1997; 68(2):151–8.KumarVKBillicaRDWaligoraJM.Utility of Doppler-detectable microbubbles in the diagnosis and treatment of decompression sickness. Aviat Space Environ Med1997; 68(2):151–8.Search in Google Scholar
Balldin UI, Pilmanis AA, Webb JT. Central nervous system decompression sickness and venous gas emboli in hypobaric conditions. Aviat Space Environ Med 2004; 75(11):969–72.BalldinUIPilmanisAAWebbJT.Central nervous system decompression sickness and venous gas emboli in hypobaric conditions. Aviat Space Environ Med2004; 75(11):969–72.Search in Google Scholar
Hagen PT, Scholz DG, Edwards WD. Incidence and Size of Patent Foramen Ovale During the First 10 Decades of Life: An Autopsy Study of 965 Normal Hearts. Mayo Clin Proc 1984; 59(1):17–20.HagenPTScholzDGEdwardsWD.Incidence and Size of Patent Foramen Ovale During the First 10 Decades of Life: An Autopsy Study of 965 Normal Hearts. Mayo Clin Proc1984; 59(1):17–20.10.1016/S0025-6196(12)60336-XSearch in Google Scholar
