Personal knowledge is a process whereby practice and research evolve simultaneously. Therefore, knowledge evolves with practice. It is a personal process, thus it creates a difficulty when identifying appropriate research methods of objectivity and analysis. Many researchers discount intuition as it is not an analytical process and cannot be studied. Rather, it is associated and absorbed through experience. Expert nurses integrate both intuitive knowledge and scientific development of intuitive skills, thereby enhancing the quality of practice. Today, scholars are beginning to understand the importance and value of expert intuition, especially in the neuroscience arena. It is this personal knowledge and intuition of expert neuroscience nurses that is the focus of this paper.