<abstract xmlns="http://www.w3.org/1999/xhtml">Empiric therapy has been applied in the treatment of Lyme disease. This therapy is selected following the sensitivity analysis of the proposed drug in all species of bacteria which can cause a similar type of infection and on the basis of the clinical efficacy of antibiotic treatment. Established schemes based on data collected from many centers in the world, including type of antibiotic, dose and duration of his administration, and the stage and form of Lyme disease have been created. Number of <italic>in vitro</italic>methods of spirochetes susceptibility to antibiotics has been also developed. Unfortunately, the lack of standardization often makes it impossible to compare the results of MIC and MBC. Furthermore, little is known about the interactions of the various antimicrobial substances and spirochetes. There is a need for testing of clinical strains isolated from patients after treatment, which would explain the problems associated with “refractory” cases of Lyme disease. The paper presents the research on the antibiotic-spirochete interactions observed <italic>in vitro</italic>.1. Introduction. 2. <italic>In vitro</italic> culture and growth <italic>of Borreliaburgdorferi</italic>sensulato. 3. <italic>In vitro</italic> susceptibility of <italic>Borreliaburgdorferi</italic>sensustricto strains to antimicrobial agents. 4. Summary</abstract>

Empiric therapy has been applied in the treatment of Lyme disease. This therapy is selected following the sensitivity analysis of the proposed drug in all species of bacteria which can cause a similar type of infection and on the basis of the clinical efficacy of antibiotic treatment. Established schemes based on data collected from many centers in the world, including type of antibiotic, dose and duration of his administration, and the stage and form of Lyme disease have been created. Number of in vitromethods of spirochetes susceptibility to antibiotics has been also developed. Unfortunately, the lack of standardization often makes it impossible to compare the results of MIC and MBC. Furthermore, little is known about the interactions of the various antimicrobial substances and spirochetes. There is a need for testing of clinical strains isolated from patients after treatment, which would explain the problems associated with “refractory” cases of Lyme disease. The paper presents the research on the antibiotic-spirochete interactions observed in vitro.1. Introduction. 2. In vitro culture and growth of Borreliaburgdorferisensulato. 3. In vitro susceptibility of Borreliaburgdorferisensustricto strains to antimicrobial agents. 4. Summary

Susceptibility of spirochetes <italic>Borreliaburgdorferi</italic>sensulato to antibiotics <italic>in vitro</italic>

Advancements of Microbiology

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Susceptibility of spirochetes sensulato to antibiotics 

<trans-abstract xml:lang="pl" xmlns="http://www.w3.org/1999/xhtml">1. Wstęp. 2. Hodowla i wzrost<italic>Borreliaburgdorferi</italic>sensulato w warunkach<italic>in vitro.</italic> 3. Wrażliwośćnaantybiotyki<italic>Borreliaburgdorferi in vitro.</italic> 4. Podsumowanie
</trans-abstract>

1. Wstęp. 2. Hodowla i wzrostBorreliaburgdorferisensulato w warunkachin vitro. 3. WrażliwośćnaantybiotykiBorreliaburgdorferi in vitro. 4. Podsumowanie

Empiric therapy has been applied in the treatment of Lyme disease. This therapy is selected following the sensitivity analysis of the proposed drug in all...

Susceptibility of spirochetes Borreliaburgdorferisensulato to antibiotics in vitro

Published Online: May 22, 2019

Page range: 335 - 339

Received: Jan 01, 2017

Accepted: Mar 01, 2017

DOI: https://doi.org/10.21307/PM-2017.56.3.335

2017 @ Author., Published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.