<abstract xmlns="http://www.w3.org/1999/xhtml"><italic>Francisella tularensis</italic> is an intracellular bacterial pathogen which causes a potentially lethal disease named tularemia. Some studies have been conducted to describe and identify the virulence factors of <italic>F. tularensis</italic>. This pathogen is able to infect a variety of cells of various hosts, including wild animals, especially rabbits, hares and rodents, and humans. This may suggest that genes of <italic>F. tularensis</italic> must adapt to many different intraorganismal environments. Still, little is known about the virulence of <italic>F. tularensis</italic>. This review focuses on the main virulence factors of <italic>F. tularensis</italic> which are involved in intramacrophage replication and its survival mechanisms during infection.1. Introduction. 2. Pathogenicity and source of infection. 3. Epidemiology. 4. Intracellular life cycle. 5. Virulence factors. 5.1. Capsule. 5.2. LPS. 5.3. Type IV Pili (Tfp). 5.4. Regulator MglA. 5.5. Francisella Pathogenity Island (FPI). 5.6. Outer membrane proteins (OMP). 5.7. Secreted proteins and secretion systems. 6. Summary1. Wstęp. 2. Chorobotwórczość, źródła i drogi zakażenia. 3. Występowanie choroby. 4. Wewnątrzkomórkowy cykl życiowy <italic>F. tularensis</italic>. 5. Czynniki zjadliwości <italic>F. tularensis</italic>. 5.1. Otoczka. 5.2. Lipopolisacharyd (LPS). 5.3. Pili typu IV. 5.4. Regulator MglA. 5.5. <italic>Francisella</italic> Pathogenity Island (FPI). 5.6. Białka błony zewnętrznej. 5.7. Białka wydzielnicze i systemy sekrecji. 6. Podsumowanie</abstract>

Francisella tularensis is an intracellular bacterial pathogen which causes a potentially lethal disease named tularemia. Some studies have been conducted to describe and identify the virulence factors of F. tularensis. This pathogen is able to infect a variety of cells of various hosts, including wild animals, especially rabbits, hares and rodents, and humans. This may suggest that genes of F. tularensis must adapt to many different intraorganismal environments. Still, little is known about the virulence of F. tularensis. This review focuses on the main virulence factors of F. tularensis which are involved in intramacrophage replication and its survival mechanisms during infection.1. Introduction. 2. Pathogenicity and source of infection. 3. Epidemiology. 4. Intracellular life cycle. 5. Virulence factors. 5.1. Capsule. 5.2. LPS. 5.3. Type IV Pili (Tfp). 5.4. Regulator MglA. 5.5. Francisella Pathogenity Island (FPI). 5.6. Outer membrane proteins (OMP). 5.7. Secreted proteins and secretion systems. 6. Summary1. Wstęp. 2. Chorobotwórczość, źródła i drogi zakażenia. 3. Występowanie choroby. 4. Wewnątrzkomórkowy cykl życiowy F. tularensis. 5. Czynniki zjadliwości F. tularensis. 5.1. Otoczka. 5.2. Lipopolisacharyd (LPS). 5.3. Pili typu IV. 5.4. Regulator MglA. 5.5. Francisella Pathogenity Island (FPI). 5.6. Białka błony zewnętrznej. 5.7. Białka wydzielnicze i systemy sekrecji. 6. Podsumowanie

<italic>Francisella tularensis</italic> – a deceitful pathogen

Advancements of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Francisella tularensis is an intracellular bacterial pathogen which causes a potentially lethal disease named tularemia. Some studies have been conducted to...

Francisella tularensis – a deceitful pathogen

Published Online: May 21, 2019

Page range: 187 - 195

Received: Sep 01, 2016

Accepted: Mar 01, 2017

DOI: https://doi.org/10.21307/PM-2017.56.2.187

© 2017 Kamila Formińska et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.