<abstract xmlns="http://www.w3.org/1999/xhtml">

Elevated levels of lead ions (Pb2+) in the bloodstream present a fatal risk to all age demographics. Furthermore, a wealth of research underscores that chronic exposure to even low, nonsymptomatic doses can trigger developmental disorders in children. Various studies have illustrated the competitive nature of Pb2+ with divalent metals from the metabolic pool, notably calcium ions (Ca2+). By exploiting transport pathways and binding sites on specific proteins, Pb2+ can infiltrate nearly every organ, including the brain. The N-methyl-D-aspartate receptor (NMDAR) is recognized as one of the key molecular targets for Pb2+. Mitochondria are also the subject of many studies investigating the toxicity of lead. Maintaining the health of the fragile developing nervous system during prenatal and neonatal stages necessitates diligent monitoring and reassessment of what constitutes safe lead ion concentrations in the bloodstream.
</abstract>

Elevated levels of lead ions (Pb2+) in the bloodstream present a fatal risk to all age demographics. Furthermore, a wealth of research underscores that chronic exposure to even low, nonsymptomatic doses can trigger developmental disorders in children. Various studies have illustrated the competitive nature of Pb2+ with divalent metals from the metabolic pool, notably calcium ions (Ca2+). By exploiting transport pathways and binding sites on specific proteins, Pb2+ can infiltrate nearly every organ, including the brain. The N-methyl-D-aspartate receptor (NMDAR) is recognized as one of the key molecular targets for Pb2+. Mitochondria are also the subject of many studies investigating the toxicity of lead. Maintaining the health of the fragile developing nervous system during prenatal and neonatal stages necessitates diligent monitoring and reassessment of what constitutes safe lead ion concentrations in the bloodstream.

Selected biochemical mechanisms of lead neurotoxicity

Pomeranian Medical University in Szczecin

Department of Biochemistry and Medical Chemistry

Pomeranian Journal of Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Selected biochemical mechanisms of lead neurotoxicity"}

Elevated levels of lead ions (Pb2+) in the bloodstream present a fatal risk to all age demographics. Furthermore, a wealth of research underscores that chronic...

Selected biochemical mechanisms of lead neurotoxicity

Published Online: Jul 16, 2023

Page range: 33 - 39

DOI: https://doi.org/10.21164/pomjlifesci.939

Keywords
divalent metals, lead, mitochondria, neurotoxicity, neurodegenerative disorders, NMDAR, oxidative stress, synaptic conduction

© 2023 Mikołaj Chlubek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Selected biochemical mechanisms of lead neurotoxicity

Published Online: Jul 16, 2023

Page range: 33 - 39

DOI: https://doi.org/10.21164/pomjlifesci.939

Keywordsdivalent metals, lead, mitochondria, neurotoxicity, neurodegenerative disorders, NMDAR, oxidative stress, synaptic conduction

© 2023 Mikołaj Chlubek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
divalent metals, lead, mitochondria, neurotoxicity, neurodegenerative disorders, NMDAR, oxidative stress, synaptic conduction