<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder among elderly individuals, after Alzheimer’s disease. This complex disorder manifests with multiple motor and non-motor features and is often diagnosed only after the onset of significant pathological symptoms. Based on the presumption that epigenetic mechanisms are involved in neurodevelopment and synaptic transmission, it is hypothesized that epigenetic alterations are closely connected to the development of PD. Several studies have reported that genetic risk factors are involved in PD susceptibilities. These factors play a prominent role in the predisposition and development of PD and may be closely linked to different metabolic pathways. In this review, we revise associations between single nucleotide polymorphisms (SNPs) and PD pathogenesis.</p>
</abstract>

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder among elderly individuals, after Alzheimer’s disease. This complex disorder manifests with multiple motor and non-motor features and is often diagnosed only after the onset of significant pathological symptoms. Based on the presumption that epigenetic mechanisms are involved in neurodevelopment and synaptic transmission, it is hypothesized that epigenetic alterations are closely connected to the development of PD. Several studies have reported that genetic risk factors are involved in PD susceptibilities. These factors play a prominent role in the predisposition and development of PD and may be closely linked to different metabolic pathways. In this review, we revise associations between single nucleotide polymorphisms (SNPs) and PD pathogenesis.

Peculiarities of some candidate gene polymorphisms in Parkinson’s disease

Pomeranian Journal of Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Peculiarities of some candidate gene polymorphisms in Parkinson\u2019s disease"}

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder among elderly individuals, after Alzheimer’s disease. This complex disorder...

Peculiarities of some candidate gene polymorphisms in Parkinson’s disease

Published Online: Jul 16, 2023

Page range: 22 - 27

DOI: https://doi.org/10.21164/pomjlifesci.893

Keywords
Parkinson’s disease, single nucleotide polymorphism, SNCA, GBA, VDR

© 2023 Aleena Parveen Shaikh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Peculiarities of some candidate gene polymorphisms in Parkinson’s disease

Published Online: Jul 16, 2023

Page range: 22 - 27

DOI: https://doi.org/10.21164/pomjlifesci.893

KeywordsParkinson’s disease, single nucleotide polymorphism, SNCA, GBA, VDR

© 2023 Aleena Parveen Shaikh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Parkinson’s disease, single nucleotide polymorphism, SNCA, GBA, VDR