<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the upper limb. Mechanical compression and local ischemia of the median nerve result in paresthesia, pain, and sensory and motoric disturbances. There are some aspects of the disease that suggest the potential role of genetic predispositions. This article presents a review of the literature about the significance of genetic factors in the etiology of CTS. It discusses the effect of selected gene mutations on constitutional and anthropometric features which may predispose to CTS. These genes are involved in the organization of an extracellular matrix architecture, as well as in bone, cartilage, and tendons development pathways. Therefore they may be potentially responsible for the observed relationship between anthropometric/constitutional factors and CTS.</p>
<p>The findings from the studies provide reliable information on the association between genetic risk factors and the development of CTS.</p>
</abstract>

Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the upper limb. Mechanical compression and local ischemia of the median nerve result in paresthesia, pain, and sensory and motoric disturbances. There are some aspects of the disease that suggest the potential role of genetic predispositions. This article presents a review of the literature about the significance of genetic factors in the etiology of CTS. It discusses the effect of selected gene mutations on constitutional and anthropometric features which may predispose to CTS. These genes are involved in the organization of an extracellular matrix architecture, as well as in bone, cartilage, and tendons development pathways. Therefore they may be potentially responsible for the observed relationship between anthropometric/constitutional factors and CTS.
The findings from the studies provide reliable information on the association between genetic risk factors and the development of CTS.

The effect of genetical factors on the risk of carpal tunnel syndrome occurrence: a review

Pomeranian Medical University in Szczecin

Pomeranian Journal of Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Carpal tunnel syndrome (CTS) is the most common compression neuropathy in the upper limb. Mechanical compression and local ischemia of the median nerve result...

The effect of genetical factors on the risk of carpal tunnel syndrome occurrence: a review

Published Online: Jul 16, 2023

Page range: 16 - 18

DOI: https://doi.org/10.21164/pomjlifesci.834

Keywords
carpal tunnel syndrome etiology, carpal tunnel syndrome – genetic predispositions, collagen synthesis, genes, genes

© 2023 Andrzej Żyluk, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The effect of genetical factors on the risk of carpal tunnel syndrome occurrence: a review

Published Online: Jul 16, 2023

Page range: 16 - 18

DOI: https://doi.org/10.21164/pomjlifesci.834

Keywordscarpal tunnel syndrome etiology, carpal tunnel syndrome – genetic predispositions, collagen synthesis, genes, genes

© 2023 Andrzej Żyluk, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
carpal tunnel syndrome etiology, carpal tunnel syndrome – genetic predispositions, collagen synthesis, genes, genes