<abstract xmlns="http://www.w3.org/1999/xhtml"><p>For many years, researchers have studied the cardioprotective properties of adenosine and attempted to use the compound in the treatment of myocardial infarction. Adenosine exhibits many other effects, as well, which can be helpful in treating complications of myocardial infarction. Over the last decade, the results of over a dozen studies conducted on animal models evaluating the possibility of using adenosine receptor agonists and antagonists in the prevention and treatment of chronic heart failure and arrhythmias after myocardial infarction have been published. This is particularly important in view of the increasing number of patients suffering from such complications, associated with increased survival rates among patients due to advancements in diagnosis and treatment of myocardial infarction itself. Current treatments for chronic heart failure and arrhythmias are mainly symptomatic and frequently are not satisfactorily effective. Cardiac remodeling, an important mechanism behind the pathogenesis of post-myocardial infarction heart failure and arrhythmias, is a promising therapeutic target.</p><p>This review presents current reports on the use of adenosine receptor agonists and antagonists as modulators of cardiac remodeling in post-myocardial infarction heart failure and arrhythmias.</p></abstract>

For many years, researchers have studied the cardioprotective properties of adenosine and attempted to use the compound in the treatment of myocardial infarction. Adenosine exhibits many other effects, as well, which can be helpful in treating complications of myocardial infarction. Over the last decade, the results of over a dozen studies conducted on animal models evaluating the possibility of using adenosine receptor agonists and antagonists in the prevention and treatment of chronic heart failure and arrhythmias after myocardial infarction have been published. This is particularly important in view of the increasing number of patients suffering from such complications, associated with increased survival rates among patients due to advancements in diagnosis and treatment of myocardial infarction itself. Current treatments for chronic heart failure and arrhythmias are mainly symptomatic and frequently are not satisfactorily effective. Cardiac remodeling, an important mechanism behind the pathogenesis of post-myocardial infarction heart failure and arrhythmias, is a promising therapeutic target.This review presents current reports on the use of adenosine receptor agonists and antagonists as modulators of cardiac remodeling in post-myocardial infarction heart failure and arrhythmias.

Adenosine receptors as therapeutic targets for the treatment of myocardial infarction and its complications. Part II. Post-myocardial infarction heart failure and arrhythmias

Pomeranian Medical University in Szczecin

Department of Biochemistry and Medical Chemistry

Pomeranian Journal of Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

For many years, researchers have studied the cardioprotective properties of adenosine and attempted to use the compound in the treatment of myocardial...

Adenosine receptors as therapeutic targets for the treatment of myocardial infarction and its complications. Part II. Post-myocardial infarction heart failure and arrhythmias

Published Online: Sep 24, 2019

Page range: 26 - 30

DOI: https://doi.org/10.21164/pomjlifesci.607

Keywords
cardiac remodeling, fibrosis, inflammation, adeno-sine, adenosine receptors, myocardial infarction

© 2020 Kamila Puchałowicz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Adenosine receptors as therapeutic targets for the treatment of myocardial infarction and its complications. Part II. Post-myocardial infarction heart failure and arrhythmias

Published Online: Sep 24, 2019

Page range: 26 - 30

DOI: https://doi.org/10.21164/pomjlifesci.607

Keywordscardiac remodeling, fibrosis, inflammation, adeno-sine, adenosine receptors, myocardial infarction

© 2020 Kamila Puchałowicz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
cardiac remodeling, fibrosis, inflammation, adeno-sine, adenosine receptors, myocardial infarction