Healing properties of geraniol – a review of the literature

1. Trytek M, Paduch R, Fiedurek J, Kandefer-Szerszeń M. Monoterpeny – stare związki, nowe zastosowania i biotechnologiczne metody ich otrzymywania. Biotechnologia 2007;1(76):135-55.Search in Google Scholar

2. Burt S. Essential oils: Their antibacterial properties and potential applications in foods – a review. Int J Food Microbiol 2004;94(3):223­53. doi:10.1016/j.ijfoodmicro.2004.03.022.10.1016/j.ijfoodmicro.2004.03.022Search in Google Scholar

3. Nowak G, Nawrot J. Surowce roślinne i związki naturalne stosowane w chorobach układu oddechowego. Herba Polonica 2009;55(4):178-213.Search in Google Scholar

4. Stevensen CJ. Aromatherapy in dermatology. Clin Dermatol 1998; 16(6):689-94.10.1016/S0738-081X(98)00058-3Search in Google Scholar

5. Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effect of essentials oils – a review. Food Chem Toxicol 2008;46(2):446-75. doi: 10.1016/j. fct.2007.09.106.Search in Google Scholar

6. Angioni A, Barra A, Coroneo V, Dessi S, Cabras P. Chemical composition, seasonal variability, and antifungal activity of Lavandula stoechas L. ssp. stoechas essential oils from stem/leaves and flowers. J Agric Food Chem 2006;54(12):4364-70. doi: 10.1021/jf0603329.10.1021/jf060332916756368Search in Google Scholar

7. Masotti V, Juteau F, Bessière JM, Viano J. Seasonal and phenological variations of the essential oil from the narrow endemic species Artemisia molinieri and its biological activities. J Agric Food Chem 2003;51(24):7115-21. doi: 10.1021/jf034621y.10.1021/jf034621y14611181Search in Google Scholar

8. Mączka W, Wińska K, Grabarczyk M, Anioł M. Właściwości biologiczne geraniolu. Post Fitoter 2016;17(1):39-43.Search in Google Scholar

9. Chen W, Viljoen AM. Geraniol – a review of a commercially important fragrance material. South African J Botany 2010;76(4):643-51. doi: 10.1016/j. sajb.2010.05.008.Search in Google Scholar

10. Babar A, Al-Wabel NA, Shams S, Ahamad A, Khan SA, Anwar F. Essential oils in aromatheraphy: A systematic review. Asian Pac J Trop Biomed 2015;5(8):601-11. doi: 10.1016/j.apjtb.2015.05.007.10.1016/j.apjtb.2015.05.007Search in Google Scholar

11. Lapczynski A, Bhatia SP, Foxenberg RJ, Letizia CS, Api AM. Fragrance material review on geraniol. Food Chem Toxicol 2008;46(11):60-70. doi: 10.1016/j.fct.2008.06.048.10.1016/j.fct.2008.06.04818640215Search in Google Scholar

12. Hagvall L, Karlberg AT, Christensson JB. Contact allergy to air­exposed geraniol: clinical observations and report of 14 cases. Contact Dermatitis 2012;67(1):20-7. doi: 10.1111/j.1600-0536.2012.02079.x.10.1111/j.1600-0536.2012.02079.x22681463Search in Google Scholar

13. Madankumar A, Jayakumar S, Gokuladhas K, Rajan B, Raghunandhakumar S, Asokkumar S, et al. Geraniol modulates tongue and hepatic phase I and phase II conjugation activities and may contribute directly to the chemopreventive activity against experimental oral carcinogenesis. Eur J Pharmacol 2013;705(1-3):148-55. doi: 10.1016/j.ejphar.2013.02.048.10.1016/j.ejphar.2013.02.04823499697Search in Google Scholar

14. Gardner JF, Peel MM. Principles of chemical disinfection. In: Gardner JF, Peel MM, editors. Introduction to sterilization, disinfection and infection control. London: Churchill Livingstone; 1991. p. 170-92.Search in Google Scholar

15. Gustafson JE, Liew YC, Chew S, Markham JL, Bell HC, Wyllie SG, et al. Effects of tea tree oil on Escherichia coli. Lett Appl Microbiol 1998;26(3): 194-8.10.1046/j.1472-765X.1998.00317.xSearch in Google Scholar

16. Helander IM, Alakomi HL, Latva-Kala K, Mattila-Sandholm T, Pol I, Smid EJ, et al. Characterization of the reaction of selected essential oil components on Gram-negative bacteria. J Agric Food Chem 1998;46(9):3590-5. doi: 10.1021/jf980154m.10.1021/jf980154mSearch in Google Scholar

17. Sikkema J, de Bont JAM, Poolman B. Interactions of cyclic hydrocarbons with biological membranes. J Biol Chem 1994;269(11):8022-8.10.1016/S0021-9258(17)37154-5Search in Google Scholar

18. Sikkema J, de Bont JAM, Poolman B. Mechanisms of membrane toxicity of hydrocarbons. Microbiol Rev 1995;59(2):201­22.10.1128/mr.59.2.201-222.1995Search in Google Scholar

19. Viuda-Martos M, Navajas YR, Zapata ES, Fernández-López J, Pérez-Alvarez JA. Antioxidant activity of essential oils of five spice plants widely used in a Mediterranean diet. Flavour Fragr J 2010;25(1):13-9. doi: 10.1002/ffj.1951.10.1002/ffj.1951Search in Google Scholar

20. Oussalah M, Caillet S, Lacroix M. Mechanism of action of Spanish oregano, Chinese cinnamon, and savory essential oils against cell membranes and walls of Escherichia coli O157:H7 and Listeria monocytogenes. J Food Prot 2006;69(5):1046-55.10.4315/0362-028X-69.5.1046Search in Google Scholar

21. Ultee A, Kets EPW, Smid EJ. Mechanisms of action of carvacrol on the food­borne pathogen Bacillus cereus. Appl Environ Microbiol 1999;10(65):4606­10.10.1128/AEM.65.10.4606-4610.1999Search in Google Scholar

22. Hada T, Shiraishi A, Furuse S, Inoue Y, Hamashima H, Matsumoto Y, et al. Inhibitory effects of terpenes on the growth of Staphylococcus aureus. Nat Med 2003;57(6):64-7.Search in Google Scholar

23. Dorman HJD, Figueiredo AC, Barroso JG, Deans SG. In vitro evaluation of antioxidant activity of essential oils and their components. Flavour Fragr J 2000;15(1):12-6. doi: 0.1002/(SICI)1099-1026(200001/02)15:1<12::AIDFFJ858>3.0.CO;2-V.10.1002/(SICI)1099-1026(200001/02)15:1<12::AID-FFJ858>3.0.CO;2-VSearch in Google Scholar

24. Carnesecchi S, Schneider Y, Ceraline J, Duranton B, Gosse F, Seiler N, et al. Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J Pharmacol Exp Ther 2001;298(1):197-200.Search in Google Scholar

25. Shoff SM, Grummer M, Yatvin MB, Elson CE. Concentration-dependent increase of murine p388 and b16 population doubling time by the acyclic monoterpene geraniol. Cancer Res 1991;51(1):37-42.Search in Google Scholar

26. Jin X, Sun J, Miao X, Liu G, Zhong D. Inhibitory effect of geraniol in combination with gemcitabine on proliferation of BXPC-3 human pancreatic cancer cells. J Int Med Res 2013;41(4):993-1001. doi: 10.1177/0300060513480919.10.1177/0300060513480919Search in Google Scholar

27. Chaudhary SC, Siddiqui MS, Athar M, Alam MS. Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis. J Appl Toxicol 2013;33(8):828-37. doi: 10.1002/jat.2739.10.1002/jat.2739Search in Google Scholar

28. Khan AQ, Khan R, Qamar W, Lateef A, Rehman MU, Tahir M, et al. Geraniol attenuates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative stress and inflammation in mouse skin: Possible role of p38 MAP kinase and NF-κB. Exp Mol Pathol 2013;94(3):419-29. doi: 10.1016/j. yexmp.2013.01.006.Search in Google Scholar

29. Kim SH, Bae HC, Park EJ, Lee CR, Kim BJ, Lee S, et al. Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways. Biochem Biophys Res Commun 2011;407(1):129-34. doi: 10.1016/j. bbrc.2011.02.124.Search in Google Scholar

30. Schnitzler P, Schuhmacher A, Astani A, Reichling J. Melissa officinalis oil affects infectivity of enveloped herpesviruses. Phytomedicine 2008;15(9):734-40. doi: 10.1016/j.phymed.2008.04.018.10.1016/j.phymed.2008.04.018Search in Google Scholar

31. Tiwari M, Kakkar P. Plant derived antioxidants – geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol In Vitro 2009;23(2):295-301. doi: 10.1016/j.tiv.2008.12.014.10.1016/j.tiv.2008.12.014Search in Google Scholar

32. El-Bassassy HM, Elberry AA, Ghareib SA. Geraniol improves the impaired vascular reactivity in diabetes and metabolic syndrome through calcium channel blocking effect. J Diabetes Complications 2016;30(6):1008-16. doi: 10.1016/j.jdiacomp.2016.04.006.10.1016/j.jdiacomp.2016.04.00627131411Search in Google Scholar

33. Wang X, Zhao S, Su M, Sun L, Zhang S, Wang D, et al. Geraniol improves endotheliol function by inhibiting NOX­2 derived oxidative stress in high fet diet fed mice. Biochem Biophys Res Commun 2016;474(1):182-7. doi: 10.1016/j.bbrc.2016.04.097.10.1016/j.bbrc.2016.04.09727107694Search in Google Scholar

34. Crespo R, Wei K, Rodenak-Kładniew B, Mercola M, Ruiz-Lozano P, Hurtado C. Effect of geraniol on rat cardiomyocytes and its potential use as a cardioprotective natural compounds. Life Sci 2017;172(3):8-12. doi: 10.1016/j.lfs.2017.01.008.10.1016/j.lfs.2017.01.00828131760Search in Google Scholar

35. Siddique YH, Naz F, Jyoti S, Ali F, Rahul AF, Khanam S. Protective effect of geraniol on the transgenic Drosophila model of Parkinson disease. Environ Toxicol Pharmacol 2016;43(4):225-31. doi: 10.1016/j.etap.2016.03.018.10.1016/j.etap.2016.03.01827026137Search in Google Scholar