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Shear wave elastography in optic neuritis: diagnostic accuracy of the optic nerve and adjacent fat tissue values

Mustafa Devran Aybar
Mustafa Devran Aybar
 and 
Onder Turna
Onder Turna
   | Sep 09, 2021
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Article Category: research-article
Published Online: Sep 09, 2021
Page range: 194 - 199
Received: Dec 20, 2020
Accepted: Feb 18, 2021
DOI: https://doi.org/10.15557/jou.2021.0031
Keywords
© 2021 Polish Ultrasound Society. Published by Medical Communications Sp. z o.o.
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Fig. 1.

A 25-year-old MS patient with left optic neuritis of 6 years’ duration, 5 days after the onset of ON attack. A. SWE images of the optic nerve, adjacent fat tissue, and circular regions of interest, respectively with 2.49 ± 0.41 m/s and 17.56 ± 4.42 kPa, and 1.87 ± 0.32 m/s and 9.65 ± 1.12 kPa. B. T1-weighted image with contrast agent shows swelling and enhancement of the optic nerve. C. Axial FLAIR image showing periventricular-pericallosal plaque formations
A 25-year-old MS patient with left optic neuritis of 6 years’ duration, 5 days after the onset of ON attack. A. SWE images of the optic nerve, adjacent fat tissue, and circular regions of interest, respectively with 2.49 ± 0.41 m/s and 17.56 ± 4.42 kPa, and 1.87 ± 0.32 m/s and 9.65 ± 1.12 kPa. B. T1-weighted image with contrast agent shows swelling and enhancement of the optic nerve. C. Axial FLAIR image showing periventricular-pericallosal plaque formations

Fig. 2.

A 32-year-old RION patient with right optic neuritis of 3 years’ duration, 7 days after the onset of ON attack. A. SWE images of the optic nerve, adjacent fat tissue, and circular regions of interest, respectively with 2.46 ± 0.31 m/s –16.46 ± 3.32 kPa and 1.82 ± 0.33 m/s – 8.36 ± 2.31 kPa. B. B-Mode US image showing swollen optic nerve. C. Axial T2W image showing swollen retrobulbar intra-orbital segment of the optic nerve, with a high T2 signal
A 32-year-old RION patient with right optic neuritis of 3 years’ duration, 7 days after the onset of ON attack. A. SWE images of the optic nerve, adjacent fat tissue, and circular regions of interest, respectively with 2.46 ± 0.31 m/s –16.46 ± 3.32 kPa and 1.82 ± 0.33 m/s – 8.36 ± 2.31 kPa. B. B-Mode US image showing swollen optic nerve. C. Axial T2W image showing swollen retrobulbar intra-orbital segment of the optic nerve, with a high T2 signal

Fig. 3.

ROC curve analysis showing a high diagnostic accuracy for determining ON with SWE values of the optic nerves (AUC 0.955 [95% CI, 0.933–0.978] in m/s and AUC 0.967 [95% CI, 0.940–0.985] in kPa. ROC curve analysis also indicated a high diagnostic accuracy for determining ON with SWE values of intraorbital fat tissue adjacent optic nerves (AUC 0.945 [95% CI, 0.935–0.965] in m/s and AUC 0.954 [95% CI, 0.936–0.975] in kPa
ROC curve analysis showing a high diagnostic accuracy for determining ON with SWE values of the optic nerves (AUC 0.955 [95% CI, 0.933–0.978] in m/s and AUC 0.967 [95% CI, 0.940–0.985] in kPa. ROC curve analysis also indicated a high diagnostic accuracy for determining ON with SWE values of intraorbital fat tissue adjacent optic nerves (AUC 0.945 [95% CI, 0.935–0.965] in m/s and AUC 0.954 [95% CI, 0.936–0.975] in kPa

Comparison of the mean optic nerve diameter and SWE values between the ON group with neuritis and the healthy control group (n = number of eyes)

ON group, neuritis side (n = 36) Healthy control group (n = 36) p
Optic nerve diameter 4.58 ± 0.23 cm 3.54 ± 0.43 cm 0.016
Optic nerve SWE value 2.49 ± 0.41 m/sand17.56 ± 4.42 kPa 1.69 ± 0.25 m/sand9.42 ± 2.24 kPa 0.006and0.004
Fat tissue adjacent optic nerve SWE value 1.87 ± 0.32 m/sand9.65 ± 1.12 kPa 1.42 ± 0.16 m/sand6.57 ± 1.15 kPa 0.025and0.022

Comparison of the mean optic nerve diameter and SWE values between the neuritis side and normal side in the ON group (n = number of eyes)

ON group, neuritis side (n = 36) ON group, normal side (n = 36) p
Optic nerve diameter 4.58 ± 0.23 cm 3.66 ± 0.58 cm 0.019
Optic nerve SWE value 2.49 ± 0.41 m/sand17.56 ± 4.42 kPa 1.71 ± 0.32 m/sand9.02 ± 2.34 kPa 0.003and0.015
Fat tissue adjacent optic nerve SWE value 1.87 ± 0.32 m/sand9.65 ± 1.12 kPa 1.47 ± 0.27 m/sand6.78 ± 1.14 kPa 0.014and0.018
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