<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec>
<h3>Objective:</h3>
<p>The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using transfontanelle ultrasonography, as well as to evaluate the risk factors for its incidence.</p>
</sec>
<sec>
<h3>Methods:</h3>
<p>We performed a retrospective cohort study using medical records of preterm newborns. The protocol for maternal corticoid administration for foetal lung maturation included dexamethasone 4 mg (intramuscular) 8/8 hours per 48 hours, with one cycle per week. The diagnosis of peri-intraventricular haemorrhage was based on transfontanelle ultrasonography, using the Papile’s classification. The following risk factors for peri-intraventricular haemorrhage were assessed: birth weight, gestational age at delivery, type of delivery, newborn’s sex, surfactant administration, premature rupture of membranes and previous history of infection during the current pregnancy. The student’s t-test and chi-square test were used for statistical analysis.</p>
</sec>
<sec>
<h3>Results:</h3>
<p>Our sample population included 184 preterm newborns. Transfontanelle ultrasonography revealed peri-intraventricular haemorrhage in 32 (74.4%) and periventricular leukomalacia in 11 (25.6%) newborns. Grade I haemorrhage was found in 20 (62.5%), grade II in five (15.6%), and grade III in seven (21.8%) newborns, as in accordance with Papile’s classification. Vaginal delivery (<italic>p</italic> = 0.010), birth weight &lt;1500 g (<italic>p</italic> = 0.024), gestational age at delivery ≤32 weeks (<italic>p</italic> = 0.018), and previous history of infection during pregnancy (<italic>p</italic> = 0.013) were considered risk factors for peri-intraventricular haemorrhage in preterm newborns.</p>
</sec>
<sec>
<h3>Conclusion:</h3>
<p>Maternal corticoid administration for foetal lung maturation showed a protective effect against peri-intraventricular haemorrhage in preterm newborns. The risk factors for peri-intraventricular haemorrhage were determined.</p>
</sec>
</abstract>

Objective:
The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using transfontanelle ultrasonography, as well as to evaluate the risk factors for its incidence.


Methods:
We performed a retrospective cohort study using medical records of preterm newborns. The protocol for maternal corticoid administration for foetal lung maturation included dexamethasone 4 mg (intramuscular) 8/8 hours per 48 hours, with one cycle per week. The diagnosis of peri-intraventricular haemorrhage was based on transfontanelle ultrasonography, using the Papile’s classification. The following risk factors for peri-intraventricular haemorrhage were assessed: birth weight, gestational age at delivery, type of delivery, newborn’s sex, surfactant administration, premature rupture of membranes and previous history of infection during the current pregnancy. The student’s t-test and chi-square test were used for statistical analysis.


Results:
Our sample population included 184 preterm newborns. Transfontanelle ultrasonography revealed peri-intraventricular haemorrhage in 32 (74.4%) and periventricular leukomalacia in 11 (25.6%) newborns. Grade I haemorrhage was found in 20 (62.5%), grade II in five (15.6%), and grade III in seven (21.8%) newborns, as in accordance with Papile’s classification. Vaginal delivery (p = 0.010), birth weight <1500 g (p = 0.024), gestational age at delivery ≤32 weeks (p = 0.018), and previous history of infection during pregnancy (p = 0.013) were considered risk factors for peri-intraventricular haemorrhage in preterm newborns.


Conclusion:
Maternal corticoid administration for foetal lung maturation showed a protective effect against peri-intraventricular haemorrhage in preterm newborns. The risk factors for peri-intraventricular haemorrhage were determined.

Antenatal corticosteroid treatment for the prevention of peri-intraventricular haemorrhage in preterm newborns: a retrospective cohort study using transfontanelle ultrasonography

Paulista School of Medicine – Federal University of São Paulo (EPM-UNIFESP)

Journal of Ultrasonography

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Objective:
The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using...

Antenatal corticosteroid treatment for the prevention of peri-intraventricular haemorrhage in preterm newborns: a retrospective cohort study using transfontanelle ultrasonography

Article Category: Original paper

Published Online: Aug 10, 2017

Page range: 91 - 95

Received: Jul 23, 2016

Accepted: Oct 04, 2016

DOI: https://doi.org/10.15557/jou.2017.0012

Keywords
corticosteroid, intraventricular haemorrhage, prematurity, transfontanelle ultrasonography

© 2017 Bianca A. Almeida et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antenatal corticosteroid treatment for the prevention of peri-intraventricular haemorrhage in preterm newborns: a retrospective cohort study using transfontanelle ultrasonography

Article Category: Original paper

Published Online: Aug 10, 2017

Page range: 91 - 95

Received: Jul 23, 2016

Accepted: Oct 04, 2016

DOI: https://doi.org/10.15557/jou.2017.0012

Keywordscorticosteroid, intraventricular haemorrhage, prematurity, transfontanelle ultrasonography

© 2017 Bianca A. Almeida et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
corticosteroid, intraventricular haemorrhage, prematurity, transfontanelle ultrasonography