<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant factor in morbidity and mortality of patients. New oral anticoagulants, such as apixaban, dabigatran, and rivaroxaban, have recently demonstrated their safety and efficacy in patients undergoing major orthopaedic surgery. Selection of the appropriate drug should be adjusted according to patient needs. Major bleeding is rare with new oral anticoagulants and is comparable with the bleeding rate associated with low-molecular-weight heparins. Clinical data indicate that therapy with apixaban and rivaroxaban was more effective compared to enoxaparin, while dabigatran has a similar efficacy to enoxaparin. Cost-effectiveness studies of new oral anticoagulants showed that these medicines offer higher efficacy with acceptable costs for the healthcare system, even saving costs in certain cases. Clinical practice in Serbia reflects considerably more frequent use of traditional anticoagulant medication therapy compared to new oral anticoagulants.</p></abstract>

Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant factor in morbidity and mortality of patients. New oral anticoagulants, such as apixaban, dabigatran, and rivaroxaban, have recently demonstrated their safety and efficacy in patients undergoing major orthopaedic surgery. Selection of the appropriate drug should be adjusted according to patient needs. Major bleeding is rare with new oral anticoagulants and is comparable with the bleeding rate associated with low-molecular-weight heparins. Clinical data indicate that therapy with apixaban and rivaroxaban was more effective compared to enoxaparin, while dabigatran has a similar efficacy to enoxaparin. Cost-effectiveness studies of new oral anticoagulants showed that these medicines offer higher efficacy with acceptable costs for the healthcare system, even saving costs in certain cases. Clinical practice in Serbia reflects considerably more frequent use of traditional anticoagulant medication therapy compared to new oral anticoagulants.

Clinical and Economic Outcomes of New Oral Anticoagulants in Orthopaedics

Department for Social Pharmacy and Pharmacy Legislation

University of Belgrade – Faculty of Pharmacy

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Clinical and Economic Outcomes of New Oral Anticoagulants in Orthopaedics"}

Venous thromboembolism, including pulmonary embolism and deep vein thrombosis, is a significant factor in morbidity and mortality of patients. New oral...

Clinical and Economic Outcomes of New Oral Anticoagulants in Orthopaedics

Published Online: Apr 11, 2018

Page range: 3 - 9

Received: Jul 29, 2016

Accepted: Aug 09, 2016

DOI: https://doi.org/10.1515/sjecr-2017-0066

Keywords
new oral anticoagulant, orthopaedic surgery, clinical outcomes, economic outcomes

© 2018 Dragana Lakic et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Clinical and Economic Outcomes of New Oral Anticoagulants in Orthopaedics

Published Online: Apr 11, 2018

Page range: 3 - 9

Received: Jul 29, 2016

Accepted: Aug 09, 2016

DOI: https://doi.org/10.1515/sjecr-2017-0066

Keywordsnew oral anticoagulant, orthopaedic surgery, clinical outcomes, economic outcomes

© 2018 Dragana Lakic et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
new oral anticoagulant, orthopaedic surgery, clinical outcomes, economic outcomes