1. bookVolume 20 (2019): Issue 2 (June 2019)
Journal Details
License
Format
Journal
eISSN
2335-075X
ISSN
1820-8665
First Published
23 Apr 2014
Publication timeframe
4 times per year
Languages
English
access type Open Access

Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery

Published Online: 30 Jul 2019
Volume & Issue: Volume 20 (2019) - Issue 2 (June 2019)
Page range: 27 - 36
Received: 02 Aug 2017
Accepted: 03 Sep 2017
Journal Details
License
Format
Journal
eISSN
2335-075X
ISSN
1820-8665
First Published
23 Apr 2014
Publication timeframe
4 times per year
Languages
English
Abstract

Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status.

The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1st, 2nd, 3rd postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO2, H2O2, O2 ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed.

QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H2O2 levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H2O2 from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O2, CAT) (p<0.05).

Women who underwent hysterectomy had significant changes of H2O2 and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.

Keywords

1. Catro-Alves LJ, De Azevedo VL, De Freitas Braga TF, Goncalves AC, De Oliveira GS Jr. The effect of neuraxial versus general anesthesia techniques on postoperative quality of recovery and analgesia after abdominal hysterectomy: a prospective, randomized, controlled trial. Anesth Analg 2011; 113: 1480-6.10.1213/ANE.0b013e3182334d8b21926374Search in Google Scholar

2. Chen JQ, Wu Z, Wen LY, Miao JZ, Hu YM, Xue R. Pre-operative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial. BMC Anesthesiol 2015; 15: 70.10.1186/s12871-015-0046-4454590725943183Search in Google Scholar

3. Allvin R, Berg K, Idvall E, Nilsson U. Postoperative recovery: a concept analysis. J Adv Nurs 2007; 57: 552-8.1728427210.1111/j.1365-2648.2006.04156.x17284272Search in Google Scholar

4. Bekker A, Haile M, Kline R, Didehvar S, Babu R, Martiniuk F, Urban M. The effect of intraoperative infusion of dexmedetomidine on quality of recovery after major spinal surgery. J Neurosurg Anesthesiol 2013; 25: 16–24.10.1097/ANA.0b013e31826318af355780022824921Search in Google Scholar

5. Freide K, Mathew JP, Podgoreanu MV. Genomic basis of perioperative medicine. In: Barash PG, Culen BF, Stoelting RK, Cahalan MK, Stock MC, Ortega R, eds. Clinical anesthesia. 7th ed. Philadelphia: Lippincott Williams and Wilkins, 2013: 130-55.Search in Google Scholar

6. Desborough JP. The stress response to trauma and surgery. Br J Anaesth 2000; 85: 109-17.10.1093/bja/85.1.10910927999Search in Google Scholar

7. Kennedy G, Spence VA, McLaren M, Hill A, Under-wood C, Belch JJ. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med 2005; 39: 584-9.10.1016/j.freeradbiomed.2005.04.02016085177Search in Google Scholar

8. Verit FF, Erel O, Sav M, Celik N, Cadirci D. Oxidative stress is associated with clinical severity of nausea and vomiting of pregnancy. Am J Perinatol 2007; 24: 545-8.1789383910.1055/s-2007-98668817893839Search in Google Scholar

9. Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: co-enzyme Q10 effect on clinical improvement. PLoS One 2012; 7(4): e35677.10.1371/journal.pone.0035677333081222532869Search in Google Scholar

10. Michel TM, Pülschen D, Thome J. The role of oxidative stress in depressive disorders. Curr Pharm Des 2012; 18: 5890-9.10.2174/13816121280352355422681168Search in Google Scholar

11. Kulacoglu H, Ozdogan M, Gurer A, Ersoy EP, Onder Devay A, Duygulu Devay S, Gulbahar O, Gogkus S. Prospective comparison of local, spinal, and general types of anaesthesia regarding oxidative stress following Lichtenstein hernia repair. Bratisl Lek Listy 2007; 108: 335-9.Search in Google Scholar

12. Mas E, Barden AE, Corcoran TB, Phillips M, Roberts LJ2nd, Mori TA. (2011). Effects of spinal or general anesthesia on F2-isoprostanes and isofurans during ischemia/reperfusion of the leg in patients undergoing knee replacement surgery. Free Radic Biol Med 2011; 50: 1171-6.Search in Google Scholar

13. Rosenfeldt F, Wilson M, Lee G, Kure C, Ou R, Braun L, de Haan J. (2013). Oxidative stress in surgery in an ageing population: pathophysiology and therapy. Exp Gerontol 2013; 48: 45-5410.1016/j.exger.2012.03.01022465624Open DOISearch in Google Scholar

14. McDonald CI, Fraser JF, Coombes JS, Fung YL. Oxidative stress during extracorporeal circulation. Eur J Cardiothorac Surg 2014; 46: 937-43.10.1093/ejcts/ezt637Open DOISearch in Google Scholar

15. McAnulty SR, Owens JT, McAnulty LS, Nieman DC, Morrow JD, Dumke CL, Milne GL. Ibuprofen use during extreme exercise: effects on oxidative stress and PGE2. Med Sci Sports Exerc 2007; 39: 1075-9.10.1249/mss.0b13e31804a8611Search in Google Scholar

16. Fricova J, Vejrazka M, Stopka P, Krizova J, Belacek J, Rokyta R. The influence of preemptive analgesia on postoperative analgesia and its objective evaluation. Arch Med Sci 2010; 6: 764–71.10.5114/aoms.2010.17093Open DOISearch in Google Scholar

17. Koelsch M, Mallak R, Graham GG, Kajer T, Milligan MK, Nguyen LQ, Newsham DW, Keh JS, Kettle AJ, Scott KF, Ziegler JB, Pattison DI, Fu S, Hawkins CL, Rees MD, Davies MJ. Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations. Biochem Pharmacol 2010; 79: 115610.1016/j.bcp.2009.11.024Open DOISearch in Google Scholar

18. Szymczyk G, Beltowski J, Marciniak A, Kotarski J. Assesment of serum lipid peroxide levels and antioxidant status in females who had undergone total abdominal hysterectomy without closing of peritoneum. Gin Pol 2003; 74: 1397-403.Search in Google Scholar

19. Szymczyk G, Bełtowski J, Marciniak A, Kotarski J. Serum isoprostanes levels in patients after abdominal hysterectomy. Rocz Akad Med Bialymst 2005; 50: 322-4.Search in Google Scholar

20. Kaur G, Mishra S, Kaur A, Sehgal A, Nageswari KS, Prasad R. Retention of ovaries and oxidative stress of surgery. Int J Gynaecol Obstet 2007; 97: 40-3.10.1016/j.ijgo.2006.11.022Search in Google Scholar

21. Fowler MA, Spiess BD. Post anesthesia recovery. In: Barash PG, Culen BF, Stoelting RK, Cahalan MK, Stock MC, eds. Clinical anesthesia 6th ed. Philadelphia: Lippincott Williams and Wilkins, 2009: 1421-43.Search in Google Scholar

22. Myles P, Weitkamp B, Jones K, Melick J, Hensen S. Validity and realibility of postoperative quality of recovery score: the QoR-40. British Journal of Anesthesia 2000; 84(1): 11-5.10.1093/oxfordjournals.bja.a013366Search in Google Scholar

23. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1975; 95: 351-8.10.1016/0003-2697(79)90738-3Search in Google Scholar

24. Green LC, Wagner, DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal Biochem 1982; 126: 131-810.1016/0003-2697(82)90118-XSearch in Google Scholar

25. Auclair C, Voisin E. Nitroblue tetrazolium reduction. In: Greenvvald RA, ed. Handbook of methods for oxygen radical research. Ine: Boka Raton, CRC Press, 1985: 123-32.Search in Google Scholar

26. Pick E, Keisari Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods 1980; 38: 161-7010.1016/0022-1759(80)90340-3Open DOISearch in Google Scholar

27. Misra HP, Fridovich I. The role of superoxide-anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247: 3170-5.10.1016/S0021-9258(19)45228-9Search in Google Scholar

28. Beutler E. Red cell metabolism: a manual of biochemical methods. 3rd ed. New York: Grune and Stratton Inc., 1984.Search in Google Scholar

29. Kane SM, Garcia-Tomas V, Alejandro-Rodriguez M, Astley B, Pollard RR. Randomized trial of transversus abdominis plane block at total laparoscopic hysterectomy: effect of regional analgesia on quality of recovery. Am J Obstet Gynecol 2012; 207: 419.e1-419.e5.10.1016/j.ajog.2012.06.05222840413Search in Google Scholar

30. Sane AS, Chokshi SA, Mishra VV, Barad DP, Shah VC, Nagpal S. Serum lipoperoxide levels in surgical stress of abdominal hysterectomy. Panminerva Med 1993; 35: 131-3.Search in Google Scholar

31. Lushchak V, Semchyshyn HM. Oxidative stress-molecular mechanisms and biological effects. Rijeka: InTech, 2012. (doi: 10.5772/2333).10.5772/2333)Open DOISearch in Google Scholar

32. Gutowski M, Kowalczyk S. A study of free radical chemistry: their role and pathophysiological significance. Acta Biochim Pol 2013; 60: 1-16.2351319210.18388/abp.2013_1944Search in Google Scholar

33. Halliwell B, Cross CE. Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect 1994; 102(Suppl 10): 5–12.10.1289/ehp.94102s10515669967705305Search in Google Scholar

34. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem 2005; 12: 1161-208.10.2174/092986705376463515892631Open DOISearch in Google Scholar

35. Gülçin I, Beydemir S, Alici HA, Elmastaş M, Büyükokuroğlu ME. In vitro antioxidant properties of morphine. Pharmacol Res 2004; 49: 59-66.10.1016/j.phrs.2003.07.01214597153Search in Google Scholar

36. Rozmer Z, Perjési P. Effect of some nonsteroid antiinflammatory drugs on Fentonreaction initiated degradation of 2-deoxy-D-ribose. Acta Pharm Hung 2005; 75: 69-75.Search in Google Scholar

37. Repetto M, Semprine J, Boveris A. Lipid peroxidation: chemical mechanism, biological implications and analytical determination. Catala A, ed. Lipid peroxidation. Rijeka: InTech, 2012. (doi: 10.5772/45943).10.5772/45943)Open DOISearch in Google Scholar

38. Cunha-Oliveira T, Silva L, Silva AM, Moreno AJ, Oliveira CR, Santos MS. Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria. Life Sci 2013; 92: 1157-64.10.1016/j.lfs.2013.04.01623680378Search in Google Scholar

39. Rokyta R, Holecek V, Pekárkova I, Krejcová J, Racek J, Trefil L, Yamamotová A. Free radicals after painful stimulation are influenced by antioxidants and analgesics. Neuro Endocrinol Lett 2003; 24: 304-9.Search in Google Scholar

40. Horid’ko TM, Hula NM, Stohniĭ NA, Mehed’ OF, Klimashevs’kyĭ VM, Shovkun SA, Kindruk NL, Berdyshev AH. Effect of N-stearoylethanolamine on the lipid peroxidation process and lipid composition of the rat liver in acute morphine intoxication. Ukr Biokhim Zh 2007; 79: 175-85.Search in Google Scholar

41. Coen M. Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity. Drug Metab Rev 2015; 47: 29-44.10.3109/03602532.2014.98286525533740Search in Google Scholar

43. Mila-Kierzenkowska C, Woźniak A, Drewa T, Woźniak B, Szpinda M, Krzyżyńska-Malinowska E, Rajewski R. Effects of open versus laparoscopic nephrectomy techniques on oxidative stress markers in patients with renal cell carcinoma. Oxid Med Cell Longev 2013; 2013: 438321.10.1155/2013/438321359692823533691Search in Google Scholar

42. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003; 31: 1499-506.10.1124/dmd.31.12.149914625346Open DOISearch in Google Scholar

44. Koźlik J, Przybyłowska J, Mikrut K, Żukiewicz-Sobczak WA, Zwoliński J, Piątek J, Sobczak P. Selected oxidative stress markers in gynecological laparoscopy. Wideochir Inne Tech Maloinwazyjne 2015; 10: 92-100.10.5114/wiitm.2014.47449441409425960799Search in Google Scholar

45. Mikhed Y, Daiber A, Steven S. Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction. Int J Mol Sci 2015; 16: 15918-53.10.3390/ijms160715918451993126184181Search in Google Scholar

46. Liao CC, Kau YC, Ting PC, Tsai SC, Wang CJ. The Effects of Volume-Controlled and Pressure-Controlled Ventilation on Lung Mechanics, Oxidative Stress, and Recovery in Gynecologic Laparoscopic Surgery. J Minim Invasive Gynecol 2016; 23: 410-7.10.1016/j.jmig.2015.12.01526772778Search in Google Scholar

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