<abstract xmlns="http://www.w3.org/1999/xhtml">Wells syndrome (WS) is a rare inflammatory skin disease of unknown etiology. Possible triggers for WS include insect bites/stings, infections, medications, malignancies, and vaccination. Most cases have been reported in adults, but WS may also occur in children.We report a case of idiopathic WS in a 12-year-old boy, who presented with pruritic papulonodular and granuloma annulare-like lesions on his legs. The patient had an excellent response to topical and systemic corticosteroids.WS may present as plaque, granuloma annulare-like, urticaria-like, papulovesicular, bullous, papulonodular, or fixed drug eruption-like lesions. Erythematous annular lesions are most common in adults, while plaques are mostly found in children. The histopathologic features are dynamic, starting with dermal edema and infiltration of eosinophils, then flame figures develop, and finishing with the appearance of histiocytes and giant cells.Our patient represents a rare pediatric case with granuloma annulare-like WS syndrome.</abstract>

Wells syndrome (WS) is a rare inflammatory skin disease of unknown etiology. Possible triggers for WS include insect bites/stings, infections, medications, malignancies, and vaccination. Most cases have been reported in adults, but WS may also occur in children.We report a case of idiopathic WS in a 12-year-old boy, who presented with pruritic papulonodular and granuloma annulare-like lesions on his legs. The patient had an excellent response to topical and systemic corticosteroids.WS may present as plaque, granuloma annulare-like, urticaria-like, papulovesicular, bullous, papulonodular, or fixed drug eruption-like lesions. Erythematous annular lesions are most common in adults, while plaques are mostly found in children. The histopathologic features are dynamic, starting with dermal edema and infiltration of eosinophils, then flame figures develop, and finishing with the appearance of histiocytes and giant cells.Our patient represents a rare pediatric case with granuloma annulare-like WS syndrome.

Granuloma Annulare-like Wells Syndrome in a Child - A Case Report

Clinic of Dermatovenereology, Clinical Center of Serbia, Belgrade, Republic of Serbia

University of Belgrade, School of Medicine, Belgrade, Republic of Serbia

Serbian Journal of Dermatology and Venereology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Granuloma Annulare-like Wells Syndrome in a Child - A Case Report"}

Wells syndrome (WS) is a rare inflammatory skin disease of unknown etiology. Possible triggers for WS include insect bites/stings, infections, medications,...

Granuloma Annulare-like Wells Syndrome in a Child - A Case Report

Published Online: Mar 20, 2017

Page range: 88 - 94

DOI: https://doi.org/10.1515/sjdv-2016-0008

Keywords
Skin Diseases, Cellulitis, Granuloma Annulare, Signs and Symptoms, Child, Eosinophilia, Diagnosis, Treatment Outcome

© 2016 Branislav Lekić et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Granuloma Annulare-like Wells Syndrome in a Child - A Case Report

Published Online: Mar 20, 2017

Page range: 88 - 94

DOI: https://doi.org/10.1515/sjdv-2016-0008

KeywordsSkin Diseases, Cellulitis, Granuloma Annulare, Signs and Symptoms, Child, Eosinophilia, Diagnosis, Treatment Outcome

© 2016 Branislav Lekić et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Skin Diseases, Cellulitis, Granuloma Annulare, Signs and Symptoms, Child, Eosinophilia, Diagnosis, Treatment Outcome