<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Drug-induced delayed multiorgan hypersensitivity syndrome, also known as drug rash (reaction) with eosinophilia and systemic symptoms (DRESS) syndrome, represents a drug-induced cluster of skin, hematologic and systemic symptoms. More than forty drugs have been associated with this syndrome. We present a case of DRESS syndrome suspecting that lamotrigine was directly responsible for the patient’s rash and other symptoms. A female patient presented with extensive skin rash, fever, hematologic abnormalities, organ involvement such as hepatitis, pancreatitis and respiratory symptoms. The symptoms developed four weeks after the initiation of the offending drug, and disappeared eight weeks after its discontinuation.</p></abstract>

Drug-induced delayed multiorgan hypersensitivity syndrome, also known as drug rash (reaction) with eosinophilia and systemic symptoms (DRESS) syndrome, represents a drug-induced cluster of skin, hematologic and systemic symptoms. More than forty drugs have been associated with this syndrome. We present a case of DRESS syndrome suspecting that lamotrigine was directly responsible for the patient’s rash and other symptoms. A female patient presented with extensive skin rash, fever, hematologic abnormalities, organ involvement such as hepatitis, pancreatitis and respiratory symptoms. The symptoms developed four weeks after the initiation of the offending drug, and disappeared eight weeks after its discontinuation.

Lamotrigine Associated DRESS Syndrome – a Case Report

Clinic of Dermatovenereology, University Hospital Clinical Centre of Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Serbian Journal of Dermatology and Venereology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Lamotrigin udružen sa DRESS sindromom – prikaz slučaja

Drug-induced delayed multiorgan hypersensitivity syndrome, also known as drug rash (reaction) with eosinophilia and systemic symptoms (DRESS) syndrome,...

Lamotrigine Associated DRESS Syndrome – a Case Report

Published Online: Dec 10, 2015

Page range: 23 - 33

DOI: https://doi.org/10.1515/sjdv-2015-0003

Keywords
Drug Hypersensitivity Syndrome, Anticonvulsants, Drug-Related Side Effects and Adverse Reactions, Antipsychotic Agents, Case Reports

© 2015 Jagoda Balaban et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Lamotrigine Associated DRESS Syndrome – a Case Report

Published Online: Dec 10, 2015

Page range: 23 - 33

DOI: https://doi.org/10.1515/sjdv-2015-0003

KeywordsDrug Hypersensitivity Syndrome, Anticonvulsants, Drug-Related Side Effects and Adverse Reactions, Antipsychotic Agents, Case Reports

© 2015 Jagoda Balaban et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Drug Hypersensitivity Syndrome, Anticonvulsants, Drug-Related Side Effects and Adverse Reactions, Antipsychotic Agents, Case Reports